Alfonso Abizaid

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Alfonso Abizaid
Associate Professor

Office: 613-520-2600 ext. 1544
Office: 329 Life Sciences Research Building

Biography

Current research in the Abizaid Lab:

  • Predominant focus is on the hormone ghrelin and how it modulates feeding, metabolism, stress, and circadian rhythms. Conducting research to elucidate how this hormone activates components of the mesolimbic dopamine system and what other systems it interacts with (e.g. endocannabinoid system) to enhance motivation and reward seeking behaviours (feeding, sex, etc.)
  • Discovering how early life developmental conditions impact the development of many adverse metabolic conditions (obesity, type 2 diabetes, metabolic syndrome, etc). For example, how early life exposure to synthetic compounds such as bisphenol-A (BPA) interferes with the development of hypothalamic circuitry involved in regulating food intake and energy expenditure.
  • Studying the role that ghrelin plays in modifying feeding and metabolism in pregnant female rats and how this affects the reproductive outcome.

Click here to read about Stress and Obesity: The Ghrelin Connection

Department of Neuroscience - Carleton University

Area of Research

Neuroendocrine Modulation of Appetitive Behaviors

In general I am interested in the way the brain integrates sensory and hormonal information to modulate feeding, reproduction and activity rhythms. One of my main interests resides in the way peripheral signals known to regulate energy balance like ghrelin and leptin modulate behaviors not only related to homeostatic regulation, but also higher order processes like motivation, emotion, and learning. I am currently working on a project where I have determined how peripheral signals like ghrelin modulate the activity of brain circuits associated with motivated behaviors. Some of the questions that I am asking in my program are: Does peripheral ghrelin reach reward circuits? Does peripheral ghrelin modulate the activity of cells in these circuits? Can ghrelin modulate reward-seeking behaviors? Are effects of ghrelin on reward circuits associated selectively to food, or do they generalize to other rewarding stimuli? Are dysfunctions in these systems associated with abnormal feeding behaviors and obesity? I believe that answers to these questions will ultimately lead to novel treatment avenues for decreasing food cravings and perhaps cravings for drugs of abuse.

Hormonal Regulation of circadian rhythms

I am also interested in the hormonal regulation of circadian behavior. Interestingly receptors for metabolic signals like ghrelin, leptin and estrogen are also found in hypothalamic centers associated with circadian rhythmicity, suggesting that these signals could potentially play a role in the regulation of daily or seasonal patterns of behavior, and endocrine function.

Aging and hypothalamic regulation

Finally, disruptions in hypothalamic centers underlying circadian rhythms produced by ageing may represent the etiology for a variety of pathological conditions that include obesity, menopause, depression, and sleep disorders. The impact of metabolic hormones, and ageing on the circadian system are also the focus of my current projects. A better understanding of how changes in these hormones during ageing affect cells in the circadian system will lead to treatments that maintain biological and behavioral rhythms functioning optimally for a longer period of time.

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