Matthew Hogan

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Matthew Hogan
Associate Professor

Room: C2, Civic CMM, Neurology
Office: 613-798-5555 ext. 16251
Work E-mail: mhogan@uottawa.ca

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Biography

Associate Investigator, Neuroscience, Ottawa Hospital Research Institute

Dr. Hogan's research is directed at the study of physiologic events occurring during acute cerebral ischemia. These investigations include both laboratory based basic science projects and clinical human imaging studies. This work relies on metabolic and functional imaging techniques and the implementation and development of these computer based imaging methodologies form a secondary area of study within Dr. Hogan's laboratory. Dr. Hogan's current projects include the following:

  • In collaboration with investigators within the departments of Neurology and Radiology at the Ottawa Hospital General Site and the Department of Rehabilitation Medicine at the Royal Ottawa Hospital, the effect of goal directed rehabilitation therapy on outcome following acute ischemic stroke will be assessed by both clinical scales and imaging techniques. Functional magnetic resonance imaging will be performed on study volunteers using activation paradigms that will explore the potential of therapy to modify patterns of functional recovery following stroke. In collaboration with investigators at the Brain Imaging Centre at the Montreal Neurological Institute a set of imaging tools will be established to provide the capability to perform quantitative analysis on the image data obtained. If a treatment effect is observed, the results of these studies may impact significantly on the future management of stroke.
  • Dr. Hogan is conducting laboratory based studies to investigate the mechanisms of ischemic preconditioning by cortical spreading depression. Preconditioning confers an ability to the brain to resist subsequent ischemic insult. The potential role of activation of both the L type voltage sensitive and the NMDA receptor linked calcium channels in this process is the focus of this work.
  • In collaboration with Drs. P. Morley and J. Tauskela at the National Research Council and A.M. Hakim at the Neuroscience Research Institute, studies will be undertaken to investigate the effect of modulation of calcium channel activation and free intracellular calcium on ischemic preconditioning. These studies will attempt to establish a link between calcium homeostasis and the ischemic preconditioning effect induced by cortical spreading depression.
  • Dr. Hogan is collaborating with other investigators at the Neuroscience Research Institute to develop new image based statistical analysis tools to investigate various metabolic events occurring in both cerebral ischemia and other disease states. Significant collaboration and interaction with other members of the Neuroscience Research Institute and University community is ongoing and these studies are undertaken in rich academic and clinical teaching environments.

Key Words:

stroke, clinical trials, cerebral ischemia, cerebral perfusion, cerebrovascular disease, ischemic tolerance, brain imaging, fMRI, ischemic penumbra, metabolic modeling, neuroprotection

Fields of Interest

  • cerebral ischemia and brain imaging
  • cerebral perfusion (CTP)and computerized tomography (CT) to identify areas of ischemic brain injury
  • functional magnetic resonance imaging (fMRI to evaluate brain function and neuroprotection
  • data drive & model free methods of analyses to evaluate recovery from ischemic stroke
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