Jérémie Lefebvre

Biography

I am a neuroscientist working at the interface of neurophysiology, neuroimaging and applied mathematics. I'm fascinated by how the brain self-organizes, diversifies and adapts - and I use math like a microscope.

How can the brain express such a rich and stable repertoire of dynamics? What happens with illnesses such as epilepsy, multiple sclerosis and depression? What can we do about it?

To answer these questions, my team and I try to bridge the gap between experiments, modeling and biomedical applications, using data, calculations and mathematics. Currently, my interdisciplinary lab explores 1) white matter plasticity and neuron-glia interactions; 2) How seizures occur in neural circuits, why, and what can we do to prevent them; 3) Optimizing neural control and non-invasive brain stimulation techniques.

If you want to know more about my research:

• What epilepsy teaches us about diversity and resilience
• Controlling thought with magnets: a promising treatment for depression
• The brain is constantly changing to make neural traffic more fluid

Selected publications

• Talidou A, Frankland P, Mabbott D, Lefebvre J. (2022) Homeostatic coordination and up-regulation of neural activity by activity-dependent myelination. Nature Computational Science (In Press)
• Rich S, Chameh H, Lefebvre J, Valiante TA (2022) Loss of neuronal heterogeneity in epileptogenic human tissue renders neural networks more susceptible to sudden changes in synchrony. Cell Reports 39 (8): 110863 (shared senior authorship)
• Hutt A, Wahl T, Voges N, Haussmann J, Lefebvre J (2021) Coherence resonance by partial stimulation in a random Erdos-Renyi network: mean-field theory. Frontiers in Applied Mathematics and Statistics. https://doi.org/10.3389/fams.2021.697904
• Skinner F, Rich S, Lunyov A, Lefebvre J, Chatzikalymniou A. (2021) A hypothesis for theta rhythm frequency control in CA1 microcircuits, Frontiers in Neural Circuits 15:31
• Noori R, Park D, Griffiths JD, Bells S, Frankland PW, Mabbott D, Lefebvre J (2020) Activity-dependent myelination: A glial mechanism of oscillatory self-organization in large-scale brain networks. Proceedings of the National Academy of Sciences (PNAS) 117 (24), 13227-13237
• Bells S, Lefebvre J, Yeh EA, Mabbott D (2019) White Matter Plasticity and Maturation in Human Cognition. Glia. doi: 10.1002/glia.23661
• Mierau A, Klimesch W, Lefebvre J. (2017) State-Dependent Alpha Peak Frequency Shifts: Experimental Evidence, Potential Mechanisms and Functional Implications. Neuroscience 360: 146-154
• Herrmann C, Ionta S, Hutt A, Murray MM, Lefebvre J. (2016) Shaping Intrinsic Oscillatory Neural Activity with Periodic Stimulation. Journal of Neuroscience 36(19):5328-37