BIOPHARMACEUTICAL SCIENCES
| 3101 | 3501 | 3901 | 3902 | 4006 | 4019 | 4101 | 4102 | 4104 | 4111 |
| 4121 | 4123 | 4125 | 4126 | 4127 | 4129 | 4504 | 4511 | 4521 | 4523 |
| 4525 | 4526 | 4527 | 4900 | 4901 | 4902 | 4903 |
| BPS3101 | Genomics | (3,0,0) 3 cr. |
| Broad introduction to genomics research, with strong emphasis on comparative genomics. Structure and organization of prokaryotic and eukaryotic genomes; gene mapping and DNA sequencing technologies; systematic methods for identification of gene function; drug discovery; proteomics. Introduction to bioinformatics and human genomic project. | ||
| Prerequisite: BIO2133. | ||
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| BPS3501 | La génomique | (3,0,0) 3 cr. |
| Introduction générale à la recherche en génomique mettant l'accent sur la génomique comparative. Structure et organisation du génome des procaryotes et eucaryotes; cartographie des gènes et technologie de séquençage d'ADN, méthodes systématiques utilisées pour l'identification de la fonction des gènes, découverte de drogues, protéomique. Introduction à la bioinformatique et au projet du génome humain. | ||
| Préalable : BIO2533. | ||
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| BPS3901 | Rapport de stage coop I / CO-OP Work Term Report I | 3 cr. |
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| BPS3902 | Rapport de stage coop II / CO-OP Work Term Report II | 3 cr. |
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| BPS4006 | Projet de recherche / Honours Project | (0,0,9) 9 cr. |
| This course is designed to prepare a student for graduate studies in the fields related to genomics. The student is assigned a research project with a designated professor and submits a thesis describing the results of the research project. Corequisite: BPS 4000. For students in their last year of Biopharmaceutical Sciences Honours program only. | ||
| Corequisite: BPS 4900. For students in their last year of Biopharmaceutical Sciences Honours program only. | ||
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| BPS4019 | Projet de recherche / Honours Project | 6 cr. |
| This course is designed to prepare a student for graduate studies in the fields related to Medicinal Chemistry. The student is assigned a research project with a designated professor and submits a thesis describing the results of the research project For students in their last year of the biopharmaceutical science honours coop program only. | ||
| (formerly BPS4917). | ||
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| BPS4101 | Human Genome Structure and Function | (3,0,0) 3 cr. |
| First half of course will focus on human chromosomes, chromatin structure, genome organization, genetic and physical mapping and the human genome project. Second half will examine the genome at the level of the gene, and covers gene structure, gene regulation, gene splicing, mRNA transport and protein synthesis. Examples of inherited and acquired genetic diseases will be discussed. | ||
| Prerequisite: BCH3170 or BIO3170. | ||
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| BPS4102 | Pharmaceuticals: Federal and International Regulations | (3,0,0) 3 cr. |
| Introduction to Canadian Acts, Regulations and Guidelines pertaining to registration of agents affecting humans, animals and/or the environment. Comparative information on international trends and regulations. Basic knowledge for preparing submission packages in support of registration of new biopharmaceutical products. Discussion on the submission review process undertaken by Canadian regulatory agencies in carrying out detailed risk assessment of new products. Not necessarily offered every year. | ||
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| BPS4104 | Bioinformatics Laboratory | (1,0,4) 3 cr. |
| Principles of organization, retrieval, manipulation, and analysis of molecular data in genomics, proteomics and transcriptomics. Hands-on analysis of these data to solve biological questions using quantitative and computational methods. | ||
| Prerequisites: BPS 3101 and BIO 3102. | ||
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| BPS4111 | Directed Studies in Biopharmaceutical Sciences | 3 cr. |
| This course involves a major literature review of a topic of current interest in the field. Upon completion of the written review the students will present and defend the key findings in a seminar. Students will chose their review subject in consultation with a professor assigned by the Program Director. For students in the last year of the Biopharmaceutical Science Honours program. | ||
| Cannot be combined for credit with BPS4006 or BPS4019. | ||
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| BPS4121 | Biosynthesis and Natural Product Derived Medicines | (3,0,0) 3 cr. |
| A study of the major biosynthetic pathways used by plants, bacteria and animals to synthesize the major families of secondary metabolites including fatty acids, phenolics, lignans, terpenes, steroids and alkaloids. The traditional use of certain natural products themselves as medicines and their value as lead compound for new drugs will be discussed. The synthesis of the natural products themselves or that of useful derivatives will also be studied. | ||
| Prerequisite: CHM3120. Cannot be combined for credit with BPS4123. | ||
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| BPS4123 | Phytomedicines and Natural Product Drugs | (3,0,0) 3 cr. |
| Ethnopharmacology and the discovery and development of natural product drugs. Phytochemistry and mode of action of major phytomedicines. Challenges in quality control and regulation. Pharmaceuticals derived from natural products. | ||
| Prerequisites: CHM2120, BIO2137. | ||
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| BPS4125 | Medicinal Chemistry | (3,0,0) 3 cr. |
| Drug design, discovery and synthesis, including structure-activity relationships, modes of action and recent therapeutic progress. Cannot be combined for credit with CHM 4123. | ||
| Prerequisite: CHM3120 or permission of the instructor. | ||
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| BPS4126 | Synthetic and Medicinal Chemistry Laboratory | (0,0,6) 3 cr. |
| The laboratory program will expose students to current methods and techniques used in the synthesis of pharmaceutical synthesis of pharmaceuticals and specialty chemicals. These include combinatorial chemistry, transition metal coupling reactions, enzyme mediated resolutions and complex carbohydrate synthesis. Products will be analyzed by modern spectroscopic methods for chemical purity and some will be tested in several biological screens. | ||
| Prerequisite: CHM3126. | ||
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| BPS4127 | Advanced Techniques in Biosciences | (0,0,6) 3 cr. |
| This laboratory course will expose students to advanced methods and techniques in biochemistry, molecular biology and cell biology. The course aims to allow a student to conduct a project involving the isolation, cloning, and expression of a gene. Gene function will be tested using biochemical and cellular assay systems. | ||
| Prerequisite: BCH3356 or BIO3151. Priority given to students in the 4th year of the Biochemistry, Biology or Biopharmaceutical Science programs who are not completing an honours research project. | ||
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| BPS4129 | Advanced Chemical Biology | (3,0,0) 3 cr. |
| This course focuses on chemical approaches to solving problems in molecular and cellular biology. Emphasis will be placed on multidisciplinary approaches to understand biological pathways and biological systems. Recent advances in chemical tool development for systems biology will be highlighted. Approaches to target selection for chemical intervention will also be covered. Topics include: chemical approaches to genomics and proteomics; protein design and engineering; chemistry in cellular imaging; chemistry in biotechnology; chemical genetics; rational and combinatorial approaches to pathway intervention; metabolic engineering. | ||
| Prerequisites: CHM2131 or CHM2132, BCH2333. Corequisites: CHM3120, BCH3170 or BIO3170. | ||
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| BPS4504 | Laboratoire de bioinformatique. | (1,0,4) 3 cr. |
| Principes d'organisation, de récupération, de manipulation et d'analyse de données moléculaires en génomique, protéomique et transcriptomique. Analyses pratiques de ces données pour résoudre des questions biologiques en utilisant des méthodes quantitatives et computationnelles. | ||
| Préalables: BPS3501 et BIO3502. | ||
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| BPS4511 | Études dirigées en sciences biopharmaceutiques | 3 cr. |
| Revue de la littérature sur un sujet d'actualité dans le domaine. Les résultats de l'étude sont présentés lors d'un séminaire. Les étudiants choisissent le sujet de l'étude en consultation avec un professeur assigné par le directeur du programme. Pour les étudiants dans leur dernière année du B.Sc. spécialisé en sciences biopharmaceutiques. | ||
| BPS4511 ne peut pas être combiné avec BPS4006 ou BPS4019. | ||
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| BPS4521 | Biosynthèse de médicaments dérivés de plantes médicinales | (3,0,0) 3 cr. |
| L'étude des voies biosynthétiques utilisées par les plantes, les bactéries et les animaux pour la synthèse d'importantes familles de métabolites secondaires, incluant les acides gras, les phénols, lignanes, terpènes, stéroïdes et alkaloïdes. L'usage traditionel de certains produits naturels comme médicaments et leurs valeurs comme substances de départ pour la synthèse de nouveaux médicaments seront étudiés. La synthèse de produits naturels ou de leurs dérivés sera aussi étudiée. | ||
| Préalable: CHM3520. BPS4521 et BPS4523 sont mutuellement exclusifs. | ||
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| BPS4523 | Produits naturels et phytomédicaments | (3,0,0) 3 cr. |
| Ethnopharmacologie; découverte et développements de médicaments provenant de produits naturels. Phytochimie et mode d'action des principaux phytomédicaments. Défis dans le contrôle de qualité et la règlementation. Produits pharmaceutiques dérivés de composés naturels. | ||
| Préalables : CHM2520, BIO2537. | ||
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| BPS4525 | Chimie médicinale | (3,0,0) 3 cr. |
| Conception, découverte et synthèse des médicaments incluant la relation entre la structure et l'activité, les modes d'action ainsi que les progrès récents en recherche thérapeutique. Les cours CHM4523 et BPS 4525 sont mutuellement exclusifs. | ||
| Préalable : CHM3520 ou permission du professeur. | ||
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| BPS4526 | Laboratoire de chimie médicinale et synthèse organique | (0,0,6) 3 cr. |
| Le programme du laboratoire exposera les étudiants aux différentes méthodes et techniques utilisées en synthèse organique. Ceci inclut la chimie combinatoire, la synthèse des hydrates de carbone complexes, résolution enzymatique et réaction de couplage utilisant les métaux de transition. Les produits seront caractérisés par spectroscopie moderne. (RMN, IR, etc.) et quelques-uns seront soumis à plusieurs tests biologiques. | ||
| Préalable : CHM3526. | ||
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| BPS4527 | Techniques avancées en biosciences | (0,0,6) 3 cr. |
| Les étudiants participant à ce cours seront exposés à des méthodes et des techniques avancées en biochimie, en biologie moléculaire et en biologie cellulaire. L'emphase sera mise sur le design expérimental et sur l'usage approprié de contôles. Le but du cours est de permettre à l'étudiant de mener à bien un projet impliquant l'isolation, le clonage et l'expression d'un gène. La fonction du gène sera étudiée en utilisant des systèmes d'essais biochimiques et cellulaires. | ||
| Préalable : BCH 3756 ou BIO3551. Priorité accordée aux étudiants et étudiantes de 4ième année des programmes de biochimie, biologie ou Sciences biopharmaceutiques qui ne sont pas inscrits au projet de recherche | ||
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| BPS4900 | Seminar | 3 cr. |
| Presentations by students on recent trends in various aspects of biopharmaceutical sciences will be discussed. For students in their last year of the Biopharmaceutical Science Honours program only. | ||
| (formerly BPS4000). | ||
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| BPS4901 | Rapport de stage coop III / CO-OP Work Term Report III | 3 cr. |
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| BPS4902 | Rapport de stage coop IV / CO-OP Work Term Report IV | 3 cr. |
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| BPS4903 | Rapport de stage coop V / CO-OP Work Term Report V | 3 cr. |
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