- Quintavalle C, Ingenito F, Roscigno G, Pattanayak B, Esposito CL, Affinito A, Fiore D, Petrillo G, Nuzzo S, Della Ventura B, D'Aria F, Giancola C, Mitola S, Grillo E, Pirozzi M, Donati G, Di Leva FS, Marinelli L, Minic Z, De Micco F, Thomas G, Berezovski MV, Condorelli G. Ex.50.T aptamer impairs tumor-stroma cross-talk in breast cancer by targeting gremlin-1. Cell Death Discov. 2025 Mar 11;11(1):94. doi: 10.1038/s41420-025-02363-6.
- Yousuf B, Mottawea W, Esmail GA, Nazemof N, Bouhlel NE, Njoku E, Li Y, Zhang X, Minic Z, Hammami R. Multi-omics unveils strain-specific neuroactive metabolite production linked to inflammation modulation by Bacteroides and their extracellular vesicles. Curr Res Microb Sci. 2025 Feb 5;8:100358. doi: 10.1016/j.crmicr.2025.100358.
- Medić A, Milićević T, Khraibah A, Herceg Romanić S, Matek Sarić M, Li Y, D'Mello R, Berezovski M, Popović A, Minić Z, Karadžić I. Total proteome and calcium-binding proteins from human breast milk: Exploring the impact of tobacco smoke exposure and environmental factors. Food Chem. 2025 Apr 30;472:142959. doi: 10.1016/j.foodchem.2025.142959.
- Landolsi C, Minic Z, Feki M, Curtis S, Hosseinian F, Harrabi S. Phenolic constituents, in silico and in vitro evaluation of anti-HMG-CoA reductase capacity of different Prunus persica extracts. European Food Research and Technology, 2025, 1-13.
- Galindo-Luján R, Pont L, Minic Z, Berezovski MV, Quispe F, Sanz-Nebot V, Benavente F.J. Comprehensive Characterization of Raw and Processed Quinoa from Conventional and Organic Farming by Label-Free Shotgun Proteomics. Agric Food Chem. 2025 Jan 29;73(4):2669-2677. doi: 10.1021/acs.jafc.4c08623.
- Mottawea W, Yousuf B, Sultan S, Ahmed T, Yeo J, Hüttmann N, Li Y, Bouhlel NE, Hassan H, Zhang X, Minic Z, Hammami R. Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling. Microbiol Spectr. 2025 Feb 4;13(2):e0136824. doi: 10.1128/spectrum.01368-24.
Publications
Publications from the Biological John L. Holmes Facility represent our dedication to rigorous scientific inquiry and innovative discoveries in biology.
2025 Publications
2024 Publications
- Miri S, Mottawea W, Leao L, Chiba M, Li Y, Minic Z, Hammami R. Ligilactobacillus-Derived Extracellular Vesicles Inhibit Growth and Virulence of Enteric Pathogens. Probiotics Antimicrob Proteins. 2024 Dec 16. doi: 10.1007/s12602-024-10423-z.
- D'Mello R, Hüttmann N, Minic Z, V Berezovski M. Untargeted metabolomic profiling of small extracellular vesicles reveals potential new biomarkers for triple negative breast cancer. Metabolomics. 2024 Nov 2;20(6):123. doi: 10.1007/s11306-024-02191-2.
- Chiba M, Miri S, Yousuf B, Esmail GA, Leao L, Li Y, Hincke M, Minic Z, Mottawea W, Hammami R. Dual bacteriocin and extracellular vesicle-mediated inhibition of Campylobacter jejuni by the potential probiotic candidate Ligilactobacillus salivarius UO.C249. Appl Environ Microbiol. 2024 Aug 21;90(8):e0084524. doi: 10.1128/aem.00845-24.
- Glazyrin YE, Veprintsev DV, Timechko EE, Minic Z, Zamay TN, Dmitrenko DV, Berezovski MV, Kichkailo AS. Comparative Proteomic Profiling of Blood Plasma Revealed Marker Proteins Involved in Temporal Lobe Epilepsy. Int J Mol Sci. 2024 Jul 20;25(14):7935. doi: 10.3390/ijms25147935.
- Li Y, Minic Z, Hüttmann N, Khraibah A, Storey KB, Berezovski MV. Proteomic analysis of Rana sylvatica reveals differentially expressed proteins in liver in response to anoxia, dehydration or freezing stress. Sci Rep. 2024 Jul 4;14(1):15388. doi: 10.1038/s41598-024-65417-2.
- Hüttmann N, Li Y, Poolsup S, Zaripov E, D'Mello R, Susevski V, Minic Z, Berezovski MV. Surface Proteome of Extracellular Vesicles and Correlation Analysis Reveal Breast Cancer Biomarkers. Cancers (Basel). 2024 Jan 25;16(3):520. doi: 10.3390/cancers16030520.
2023 Publications
- Vahkal B, Altosaar I, Tremblay E, Gagné D, Hüttman N, Minic Z, Côté M, Blais A, Beaulieu JF, Ferretti E.J Extracell Biol. Gestational age at birth influences protein and RNA content in human milk extracellular vesicles. 2023 Dec 27;3(1):e128. doi: 10.1002/jex2.128.
- Inui H, Minic Z, Hüttmann N, Fujita K, Stoykova P, Karadžić I.J Plant Physiol. Cucurbita pepo contains characteristic proteins without a signal peptide in the xylem sap. 2023 Aug; 287:154038. doi: 10.1016/j.jplph.2023.154038.
- Kolovskaya OS, Zyuzyukina AV, Dassie JP, Zamay GS, Zamay TN, Boyakova NV, Khorzhevskii VA, Kirichenko DA, Lapin IN, Shchugoreva IA, Artyushenko PV, Tomilin FN, Veprintsev DV, Glazyrin YE, Minic Z, Bozhenko VK, Kudinova EA, Kiseleva YY, Krat AV, Slepov EV, Bukatin AS, Zukov RA, Shesternya PA, Berezovski MV, Giangrande PH, Kichkailo AS. Monitoring of breast cancer progression via aptamer-based detection of circulating tumor cells in clinical blood samples. Front Mol Biosci. 2023 Jun 8;10:1184285. doi: 10.3389/fmolb.2023.1184285.
- Minic Z, Li Y, Hüttmann N, Uppal GK, D'Mello R, Berezovski MV.Biomedicines. Lysine Acetylome of Breast Cancer-Derived Small Extracellular Vesicles Reveals Specific Acetylation Patterns for Metabolic Enzymes. 2023 Apr 2;11(4):1076. doi: 10.3390/biomedicines11041076.
- Li Y, Hüttmann N, Minic Z, Berezovski MV. Proteomics Approaches for the Discovery of Potential Enzymatic Biomarkers for Early Diagnosis of Breast Cancer. Medical Sciences Forum, 2023, 21 (1), 5
- Izrael Živković L, Hüttmann N, Susevski V, Medić A, Beškoski V, Berezovski MV, Minić Z, Živković L, Karadžić I. A comprehensive proteomics analysis of the response of Pseudomonas aeruginosa to nanoceria cytotoxicity. Nanotoxicology. 2023, Feb;17(1):20-41. doi: 10.1080/17435390.2023.2180451.
- Poolsup S, Zaripov E, Hüttmann N, Minic Z, Artyushenko PV, Shchugoreva IA, Tomilin FN, Kichkailo AS, Berezovski MV.Mol Ther Nucleic Acids. Discovery of DNA aptamers targeting SARS-CoV-2 nucleocapsid protein and protein-binding epitopes for label-free COVID-19 diagnostics. 2023 Mar 14;31:731-743. doi: 10.1016/j.omtn.2023.02.010.
2022 Publications
- Provost Z, Hansen EO, Lynds MV, Flinn BS, Minic Z, Berezovski MV, Altosaar I. Three Diverse Granule Preparation Methods for Proteomic Analysis of Mature Rice (Oryza sativa L.) Starch Grain. Molecules. 2022 May 21;27(10):3307. doi: 10.3390/molecules27103307
- Pane K, Quintavalle C, Nuzzo S, Ingenito F, Roscigno G, Affinito A, Scognamiglio I, Pattanayak B, Gallo E, Accardo A, Thomas G, Minic Z, Berezovski MV, Franzese M, Condorelli G. Comparative Proteomic Profiling of Secreted Extracellular Vesicles from Breast Fibroadenoma and Malignant Lesions: A Pilot Study. Int J Mol Sci. 2022 Apr 3;23(7):3989. doi: 10.3390/ijms23073989.
- Medić A, Hüttmann N, Lješević M, Risha Y, Berezovski MV, Minić Z, Karadžić I. A study of the flexibility of the carbon catabolic pathways of extremophilic P. aeruginosa san ai exposed to benzoate versus glucose as sole carbon sources by multi omics analytical platform. Microbiol Res. 2022 Jun;259:126998. doi: 10.1016/j.micres.2022.126998.
- Minic Z, Hüttmann N, Poolsup S, Li Y, Susevski V, Zaripov E, Berezovski MV. Phosphoproteomic Analysis of Breast Cancer-Derived Small Extracellular Vesicles Reveals Disease-Specific Phosphorylated Enzymes. Biomedicines. 2022 Feb 9;10(2):408. doi: 10.3390/biomedicines10020408.
- Allameh A, Hüttmann N, Charlebois E, Katsarou A, Gu W, Gkouvatsos K, Pasini E, Bhat M, Minic Z, Berezovski M, Guido M, Fillebeen C, Pantopoulos K. Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma.Commun Biol. 2022 Feb 22;5(1):153. doi: 10.1038/s42003-022-03108-2.
2021 Publications
- Galindo-Luján R, Pont L, Minic Z, Berezovski MV, Sanz-Nebot V, Benavente F. Characterization and differentiation of quinoa seed proteomes by label-free mass spectrometry-based shotgun proteomics. Food Chem. 2021 Nov 30;363:130250. doi: 10.1016/j.foodchem.2021.130250.
- Risha Y, Susevski V, Hüttmann N, Poolsup S, Minic Z, Berezovski MV. Breast Cancer-Derived Microvesicles Are the Source of Functional Metabolic Enzymes as Potential Targets for Cancer Therapy. Biomedicines. 2021 Jan 22;9(2):107. doi: 10.3390/biomedicines9020107.
- Rizzolo K, Yu AYH, Ologbenla A, Kim SR, Zhu H, Ishimori K, Thibault G, Leung E, Zhang YW, Teng M, Haniszewski M, Miah N, Phanse S, Minic Z, Lee S, Caballero JD, Babu M, Tsai FTF, Saio T, Houry WA. Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex. Nat Commun. 2021 Jan 12;12(1):281. doi: 10.1038/s41467-020-20553-x.
2020 Publications
- Risha Y, Minic Z, Ghobadloo SM, Berezovski MV. The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers. Sci Rep. 2020 Aug 11;10(1):13572. doi: 10.1038/s41598-020-70393-4.
- Glazyrin YE, Veprintsev DV, Ler IA, Rossovskaya ML, Varygina SA, Glizer SL, Zamay TN, Petrova MM, Minic Z, Berezovski MV, Kichkailo AS. Proteomics-Based Machine Learning Approach as an Alternative to Conventional Biomarkers for Differential Diagnosis of Chronic Kidney Diseases. Int J Mol Sci. 2020 Jul 7;21(13):4802. doi: 10.3390/ijms21134802.
- Affinito A, Quintavalle C, Esposito CL, Roscigno G, Giordano C, Nuzzo S, Ricci-Vitiani L, Scognamiglio I, Minic Z, Pallini R, Berezovski MV, de Francisis V, Condorelli G. Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells. Mol Ther Nucleic Acids. 2020 Jun 5;20:176-185. doi: 10.1016/j.omtn.2020.02.005.
- Pero-Gascon R, Benavente F, Minic Z, Berezovski MV, Sanz-Nebot V.On-line Aptamer Affinity Solid-Phase Extraction Capillary Electrophoresis-Mass Spectrometry for the Analysis of Blood α-Synuclein. Anal Chem. 2020 Jan 7;92(1):1525-1533. doi: 10.1021/acs.analchem.9b04802.
2019 Publications
- Moutaoufik MT, Malty R, Amin S, Zhang Q, Phanse S, Gagarinova A, Zilocchi M, Hoell L, Minic Z, Gagarinova M, Aoki H, Stockwell J, Jessulat M, Goebels F, Broderick K, Scott NE, Vlasblom J, Musso G, Prasad B, Lamantea E, Garavaglia B, Rajput A, Murayama K, Okazaki Y, Foster LJ, Bader GD, Cayabyab FS, Babu M. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. iScience. 2019 Sep 27;19:1114-1132. doi: 10.1016/j.isci.2019.08.057.
- Santiago-Cartagena E, González-Crespo S, Vélez V, Martínez N, Snider J, Jessulat M, Aoki H, Minic Z, Akamine P, Mejías I, Pérez LM, Rymond BC, Babu M, Stagljar I, Rodríguez-Medina JR. Identification and Functional Testing of Novel Interacting Protein Partners for the Stress Sensors Wsc1p and Mid2p of Saccharomyces cerevisiae. G3 (Bethesda). 2019 Apr 9;9(4):1085-1102. doi: 10.1534/g3.118.200985.
2018 Publications
- Minic Z, Dahms TES, Babu M.Chromatographic separation strategies for precision mass spectrometry to study protein-protein interactions and protein phosphorylation. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Dec 1;1102-1103:96-108. doi: 10.1016/j.jchromb.2018.10.022.
- Rizzolo K, Kumar A, Kakihara Y, Phanse S, Minic Z, Snider J, Stagljar I, Zilles S, Babu M, Houry WA. Systems analysis of the genetic interaction network of yeast molecular chaperones. Mol Omics. 2018 Apr 16;14(2):82-94. doi: 10.1039/C7MO00142H.
- Jun D, Minic Z, Bhat SV, Vanderlinde EM, Yost CK, Babu M, Dahms TES. Metabolic Adaptation of a C-Terminal Protease A-Deficient Rhizobium leguminosarum in Response to Loss of Nutrient Transport. Front Microbiol. 2018 Jan 4;8:2617. doi: 10.3389/fmicb.2017.02617.
- Babu M, Bundalovic-Torma C, Calmettes C, Phanse S, Zhang Q, Jiang Y, Minic Z, Kim S, Mehla J, Gagarinova A, Rodionova I, Kumar A, Guo H, Kagan O, Pogoutse O, Aoki H, Deineko V, Caufield JH, Holtzapple E, Zhang Z, Vastermark A, Pandya Y, Lai CC, El Bakkouri M, Hooda Y, Shah M, Burnside D, Hooshyar M, Vlasblom J, Rajagopala SV, Golshani A, Wuchty S, F Greenblatt J, Saier M, Uetz P, F Moraes T, Parkinson J, Emili A. Global landscape of cell envelope protein complexes in Escherichia coli. Nat Biotechnol. 2018 Jan;36(1):103-112. doi: 10.1038/nbt.4024.
Contact Us
Biological facility
Zoran Minic
[email protected]
Marion Hall - Room 02
Ottawa, ON K1N 1A2
Tel: 613-562-5800 ext. 1626