Biographie
Intérêts de recherche
La pollution de l'air est le principal facteur de risque environnemental pour la mortalité au Canada et dans le monde. Le laboratoire du Dr Thomson étudie les mécanismes sous-jacents aux impacts sur la santé des polluants atmosphériques et identifie les déterminants clés de la toxicité.
Les efforts de recherche actuels comprennent :
- Élucider les mécanismes sous-jacents aux effets sur la santé des polluants atmosphériques
- Identifier les facteurs de susceptibilité aux polluants
- Identifier les déterminants de la toxicité dans les mélanges atmosphériques complexes provenant de diverses sources
- Établir des outils d'exposition par inhalation in vitro
- Traduire les découvertes en laboratoire dans le contexte humain et populationnel
Sélection des publications
- Thomson EM, Christidis T, Pinault L, Tjepkema M, Colman I, Crouse DL, van Donkelaar A, Martin RV, Hystad P, Robichaud A, Ménard R, Brook JR, Burnett RT. 2020. Self-rated stress, distress, mental health, and health as modifiers of the association between long-term exposure to ambient pollutants and mortality. Environmental Research, in press.
- Rose M, Filiatreault A, Guenette J, Williams A, Thomson EM. 2020. Ozone Increases plasma kynurenine-tryptophan ratio and impacts hippocampal serotonin receptor and neurotrophic factor expression. Environmental Research 185:109483.
- Thomson EM. 2020. Air pollution, stress, and allostatic load: linking systemic and central nervous system impacts. Journal of Alzheimer’s Disease, 69(3):597-614.
- Bushnik T, Wong S, Holloway AC, Thomson EM. 2019. Association of urinary polycyclic aromatic hydrocarbons and obesity in children ages 3 to 18: Canadian Health Measures Survey 2009-2015. Journal of Developmental Origins of Health and Disease, Dec 6:1-9. doi: 10.1017/S2040174419000825.
- Thomson EM, Filiatreault A, Guénette J. 2019. Stress hormones as potential mediators of air pollutant effects on the brain: Rapid induction of glucocorticoid-responsive genes. Environmental Research. 2019 Nov;178:108717.
- Thomson EM, Kalayci H, Walker M. 2019. Cumulative toll of exposure to stressors in Canadians: an allostatic load profile. Health Reports 30(6):14-21.
- Thomas J, Guénette J, Thomson EM. 2018. Stress axis variability is associated with differential ozone-induced lung injury and inflammation. Environmental Research 167:751-758.
- Thomson EM, Breznan D, Karthikeyan S, MacKinnon-Roy C, Vuong NQ, Dabek-Zlotorzynska E, Celo V, Charland J-P, Kumarathasan P, Brook JR, Vincent R. 2016. Contrasting biological potency of particulate matter collected at sites impacted by distinct industrial sources. Particle and Fibre Toxicology 13(1):65.
- Thomson EM, Pal S, Guénette J, Wade MG, Atlas E, Holloway AC, Williams A, Vincent R. 2016. Ozone inhalation provokes glucocorticoid-dependent and independent effects on inflammatory and metabolic pathways. Toxicological Sciences 152(1):17-28.
- Thomson EM, Breznan D, Karthikeyan S, MacKinnon-Roy C, Charland J-P; Dabek-Zlotorzynska E, Celo V, Kumarathasan P, Brook JR, Vincent R. 2015. Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area. Particle and Fibre Toxicology 12(1):24.
- Liu Y, Liggio J, Li S-M, Breznan D, Vincent R, Thomson EM, Kumarathasan P, Das D, Abbatt J, Antiñolo M, Russell L. 2015. Chemical and toxicological evolution of carbon nanotubes during atmospherically relevant aging processes. Environ. Sci. Tech. 49(5):2806-14.
- Thomson EM, Vladisavljevic D, Mohottalage S, Kumarathasan P, Vincent R. 2013. Mapping acute systemic effects of inhaled particulate matter and ozone: multi-organ gene expression and glucocorticoid activity. Toxicological Sciences 135(1): 169-181.
- Thomson EM, Williams A, Yauk CL, Vincent R. 2012. Overexpression of tumour necrosis factor-α in the lungs alters immune response, matrix remodelling, and repair and maintenance pathways. Am J Pathol 180: 1413-30.
- Thomson E, Williams A, Yauk C, Vincent R. 2009. Toxicogenomic analysis of susceptibility to inhaled particles in mice with chronic lung inflammation. Particle and Fibre Toxicology 6:6.