Yan Burelle
Yan Burelle
Full Professor
University Research Chair in Integrative Mitochondrial Biology
Department of Cellular and Molecular Medicine, Faculty of Medicine

2002 - Post-Doctoral Fellowship in Comparative Biochemistry, Department of Zoology, University of British Columbia, Vancouver, Canada
2000 - Ph.D. in Exercise Sciences, Département de Kinésiologie, Université de Montréal, Montréal, Canada
1996 - Master's, Exercise Sciences, Département de Kinésiologie, Université de Montréal, Montréal, Canada

RGN 2131


Over the past 18 years, I have developed a research program that focusses on integrative mitochondrial biology. As such, my laboratory has built strong expertise in the analysis of many facets of mitochondria, with the ability to combine detailed mechanistic studies with the analysis of functional repercussions in isolated organelles, permeabilized or intact cells, mouse models of disease, and fibroblasts or muscle biopsies from patients. Beyond bioenergetics and metabolism, our group has actively studied processes such as reactive oxygen species (ROS) metabolism and permeability transition pore opening, as well as mitochondrial quality control mechanisms, such as mitophagy and the shedding of mitochondrial-derived vesicles. In all our work, we successfully merge cutting-edge imaging and molecular techniques with omics and functional analyses to gain valuable insights into the basic biology of these organelles and to better understand their role in the pathophysiology of genetic and acquired diseases. 

Professor Burelle is accepting new students for thesis supervision.

Research interests

  • Role of mitochondria in the pathogenesis of myopathies and cardiomyopathies
  • Pathogenesis and treatment of genetic mitochondrial diseases


Complete publications: Google Scholar

  • Cuillerier A, Ruiz M, Daneault C, Forest A, Rossi J, Vasam G, Cairns G, Cadete V; LSFC Consortium, Des Rosiers C, Burelle Y. Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice. Commun Biol. 2021 Aug 19;4(1):989. doi: 10.1038/s42003-021-02492-5. PMID: 34413467; PMCID: PMC8376967.
  • Vasam G, Nadeau R, Cadete VJJ, Lavallée-Adam M, Menzies KJ, Burelle Y. Proteomics characterization of mitochondrial-derived vesicles under oxidative stress. FASEB J. 2021 Apr;35(4):e21278. doi: 10.1096/fj.202002151R. PMID: 33769614; PMCID: PMC8252493.
  • Cairns G, Thumiah-Mootoo M, Burelle Y, Khacho M. Mitophagy: A New Player in Stem Cell Biology. Biology (Basel). 2020 Dec 19;9(12):481. doi: 10.3390/biology9120481. PMID: 33352783; PMCID: PMC7766552.
  • Cadete VJJ, Vasam G, Menzies KJ, Burelle Y. Mitochondrial quality control in the cardiac system: An integrative view. Biochim Biophys Acta Mol Basis Dis. 2019 Apr 1;1865(4):782-796. doi:  0.1016/j.bbadis.2018.11.018. Epub 2018 Nov 22. PMID: 30472159.
  • Cuillerier A, Honarmand S, Cadete VJJ, Ruiz M, Forest A, Deschênes S, Beauchamp C; LSFC Consortium, Charron G, Rioux JD, Des Rosiers C, Shoubridge EA, Burelle Y. Loss of hepatic LRPPRC alters mitochondrial bioenergetics, regulation of permeability transition and trans-membrane ROS diffusion. Hum Mol Genet. 2017 Aug 15;26(16):3186-3201. doi: 10.1093/hmg/ddx202. PMID: 28575497; PMCID: PMC5886084.
  • Cadete VJ, Deschênes S, Cuillerier A, Brisebois F, Sugiura A, Vincent A, Turnbull D, Picard M, McBride HM, Burelle Y. Formation of mitochondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system. J Physiol. 2016 Sep 15;594(18):5343-62. doi:10.1113/JP272703. Epub 2016 Jul 24. PMID: 27311616; PMCID: PMC5023710.
  • Piquereau J, Godin R, Deschênes S, Bessi VL, Mofarrahi M, Hussain SN, Burelle Y. Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction. Autophagy. 2013 Nov 1;9(11):1837-51. doi: 10.4161/auto.26502. Epub 2013 Oct 3. PMID: 24121678.
  • Mofarrahi M, Guo Y, Haspel JA, Choi AM, Davis EC, Gouspillou G, Hepple RT, Godin R, Burelle Y, Hussain SN. Autophagic flux and oxidative capacity of skeletal muscles during acute starvation. Autophagy. 2013 Oct;9(10):1604-20. doi: 10.4161/auto.25955. Epub 2013 Aug 15. PMID: 23955121.
  • Ruiz M, Cuillerier A, Daneault C, Deschênes S, Frayne IR, Bouchard B, Forest A, Legault JT; LSFC Consortium, Vaz FM, Rioux JD, Burelle Y, Des Rosiers C. Lipidomics unveils lipid dyshomeostasis and low circulating plasmalogens as biomarkers in a monogenic mitochondrial disorder. JCI Insight. 2019 Jul25;4(14):e123231. doi: 10.1172/jci.insight.123231. PMID: 31341105; PMCID: PMC6675547.
  • Gouspillou G, Godin R, Piquereau J, Picard M, Mofarrahi M, Mathew J, Purves- Smith FM, Sgarioto N, Hepple RT, Burelle Y, Hussain SNA. Protective role of Parkin in skeletal muscle contractile and mitochondrial function. J Physiol. 2018 Jul;596(13):2565-2579. doi: 10.1113/JP275604. Epub 2018 May 30. PMID:29682760; PMCID: PMC6023825.