Dr. Ashok Kumar

Biography

Areas of Clinical Expertise

• Immunology

Areas of Laboratory Medicine Expertise

• Virology and Immunology

Recent Publications

• Jonathan Boucher, Kelley Parato, Fiona Frappier, Wei Ma, Niranjala Gajanayaka, Robin Parks, Ashok Kumar, and Jonathan Angel. 2009.Disparate regulation of LPS-induced MAPK signalling and IL-12p40 expression between different myeloid cell types with and without HIV infection" Under revision by Viral Immunology.
• Aurelia Busca, Mansi Saxena, Marko Kryworuchko and Ashok Kumar. 2009. Anti-apoptotic Genes in the Survival of Monocytic Cells During Infection. Current Genomics. Volume 10, Number 5, August 2009 , pp. 306-317(12).
• Anita Benoit, Khaled Abdkader, Danylo Siskyj, Abdulkarim Alhetheel, Nadia Sant, Ashok Kumar, Francisco Diaz-Mitoma, Marko Kryworuchko. 2009. Reduced IL-7R expression in CD8 T cells from HIV+ patients is associated with the transcriptional repressor Gfi-1 and impaired STAT activation in response to IL-7 but not IL-2, IL-15, IL-4, and IL-10 AIDS. Jul 17;23(11):1341-7. 
• Katrina Gee, Christina Guzzo, Nor Fazila Che Mat, and Ashok Kumar 2009. The IL-12 Family of Cytokines in Infection, Inflammation and Autoimmune Disorders. Inflammation and Allergy- Drug Targets. 8(1):40-52.
• Wei Ma, Sasmita Mishra, Jonathan B. Angel and Ashok Kumar. 2009 Intracellular HIV-1 nef interferes with LPS signaling through JNK-activated NFkB pathway and inhibits IL-12p40 production in human monocytic cells. Journal of Biological Chemistry. 284(12):7578-87.
• Alhetheel, A .,  Yakubtsov, Y., Abdkader, K , Sant, N , Diaz-Mitoma, F., Kumar, A., and Kryworuchko, M  2008. Amplification of the STAT1 signaling pathway and its association with apoptosis in monocytes from HIV-infected patients. AIDS. 22(10):1137-44.
• Sirskyj D., Kumar A, Theze J and Kryworuchko M. 2007 Disruption of gc cytokine network in T cells during HIV infection. Cytokine. 43(1):1-14.
• Vranjkovic A., Crawley AM., Gee K., Kumar A., Angel JB. 2007. "IL-7 decreases IL-7 receptor-a (CD127) expression and induces shedding of CD127 by human CD8+ T cells" International Immunology, 19(12):1329-39.
• Ma, W., Sasmita Mishra, Katrina Gee, Jyoti P. Mishra, Jonathan B. Angel, and Ashok Kumar 2007. Cyclosporin A and FK506 Inhibit Human IL-12-40 Production through the Calmodulin / Calmodulin-dependent Protein Kinase and PI3K Pathways in LPS-Stimulated Human Monocytic Cells: Evidence for Calcium Signalling and PI3 Kinase as Positive Regulators of IL-12p40 Production. Journal of Biological Chemistry 282(18):13351-62.
• Gee K, Angel JB, Ma W, Mishra S, Gajanayaka N, Parato K, Kumar A 2007. Intracellular HIV-Tat expression induces. IL-10 synthesis by the CREB-1 transcription factor through Ser 133 phosphorylation and its regulation y the ERK 1/2 MAPK in human monocytic cells. Journal of Biological Chemistry 281(42):31647-58.
• Sasmita Mishra, Jyoti P. Mishra and Ashok Kumar  2007.  Activation of JNK-dependent pathway is required for HIV-Vpr-induced apoptosis in human monocytic cells: involvement of anti-apoptotic Bcl2 and c-IAP-1 genes. J. Biol. Chem. 282: 4288-4300.
• Katrina Gee, Jonathan B. Angel, Sasmita Mishra, and Ashok Kumar 2007. HIV-TAT induces IL-10 expression via calcium-dependent p38 MAPK induced SP-1 and CREB1 activation in primary human monocytic cells. J. Immunology,178(2):798-807.
• Creery D, William Weiss, Gina Graziani-Bowering, Ritesh Kumar, Zared Aziz, Jonathan B. Angel, and Ashok Kumar. 2006. Differential Regulation of CXCR4 and CCR5 Expression by IL-4 and IL-13 is Associated with Inhibition of Chemotaxis and HIV-1 Replication but not HIV Entry into Human Monocytes. Viral Immunology 19(3):409-23
• Sasmita Mishra, Jyoti P. Mishra, Katrina Gee, Dan C McManus, Eric C LaCasse and Ashok Kumar 2005 Distinct role of calmodulin and calmodulin-dependent protein kinase-ii in lipopolysaccharide and tumor necrosis factor-a-mediated suppression of apoptosis and antiapoptotic c-iap2 gene expression in human monocytic cells. Journal of Biological Chemistry: 280(45):37536-46
• W. Lim, K. Gee, and A. Kumar. 2005. Regulation of B7.1 Co-stimulatory Molecule is Mediated by the Interferon Regulatory Factor-7 Through the Activation of c-Jun N-Terminal Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells. Journal of Immunology: 175(9):5690-700
• Prasad, J., S. Mishra, K. Gee and A. Kumar. 2005. Differential Involvement of Calmodulin-dependent Protein Kinase-II-activated AP-1 and c-jun-N-Terminal Kinase-activated Egr-1 Signaling Pathways in Tumor Necrosis Factor-a and Lipopolysaccharide-induced CD44 Expression In Human Monocytic Cells. Journal of Biological Chemistry. Jul 22;280(29):26825-37
• Rahimi, AAR., K. Gee, S. Mishra, W. Lim, K. Gee and A. Kumar 2005.  STAT-1 mediates the stimulatory effects of IL-10 on CD14 expression in human monocytic cells. Journal of Immunology. Jun 15;174(12):7823-32