Dr. Blair Gage
Dr. Blair Gage
Assistant Professor, Department of Cellular and Molecular Medicine | Scientist, Regenerative Medicine Program Ottawa Hospital Research Institute


Blair K. Gage (PhD) is a Scientist at the Ottawa Hospital Research Institute in the Regenerative Medicine Program. He completed his postdoctoral studies with Dr. Gordon Keller at the McEwen Stem Cell Institute (Toronto, ON) after a PhD in Cell and Developmental Biology with Dr. Timothy Kieffer at the University of British Columbia (Vancouver, BC). His PhD work explored how transcription factors regulate the pancreatic endocrine cell subtypes that are formed from stem cells including human pluripotent stem cells. His postdoctoral work shifted to generate liver endothelium from human pluripotent stem cells to create potential cell-based and cell-informed therapeutics for liver disease and Hemophilia A. Before becoming an independent investigator at the OHRI in December 2023, Dr. Gage acquired numerous competitive funding scholarships and fellowships including those from NSERC, CIHR, Michael Smith Foundation, and Stem Cell Network.

Selected Publications

  • Gage BK, Merlin S, Olgasi C, Follenzi A, Keller GM. Therapeutic Correction of Hemophilia A by Transplantation of hPSC-derived Liver Sinusoidal Endothelial Cell Progenitors. Cell Rep. (2022) 39(1): 110621.
  • Gage BK, Liu JC, Innes BT, MacParland SA, McGilvray ID, Bader GD, Keller GM. Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem Cell-Derived Venous Angioblasts. Cell Stem Cell. (2020) 27(2): 254-269 e259.

Research interests

  • Blood disorders
  • Liver cancer
  • Liver disease
  • Vascular heart and metabolic disease
  • Bioinformatics
  • Cell Therapy
  • Gene therapy
  • Genetics
  • Genomics
  • Molecular and cellular biology
  • Regenerative medicine
  • Stem cells
  • Translational research
  • Transplantation
  • Disease models