Dr. Lisheng Wang

Biography

Biographical Sketch

Dr. Lisheng Wang is a Professor in the Department of Biochemistry, Microbiology, and Immunology at University of Ottawa, a Core Member at the Ottawa Institute of Systems Biology, and an Affiliated Investigator at the Ottawa Health Research Institute. He graduated from Medical School in China and received his clinical training as a Fellow in Australian National Liver Transplantation Unit. Dr. Wang completed a PhD at the University of Sydney (Australia) studying the transplantation immunology. He then pursued postdoctoral research in immunology at Harvard Medical School, USA, and further postdoctoral research in stem cell biology and regenerative medicine at Robarts Research Institute, Canada.

Research Interests

Using cellular and molecular approaches and in vivo animal models, Dr. Wang’s laboratory is interested in:

1. Nurturing human embryonic stem cells (hESCs) into mothers of circulatory cells and immune cells for stem cell-based clinic therapy and reducing transplantation rejection;
2. Targeting embryonic signaling pathways in breast cancer for more effective treatment.

For further information, please contact Dr. Lisheng Wang at 613-562-5624 or [email protected]

Selected Publications (from 80 articles)​​​​​​

• Zikuan Gu, Yueru Dong, Shuxin Xu, Lisheng Wang and Zhen Liu. Molecularly imprinted polymer-based smart prodrug delivery system for specific targeting, prolonged retention and tumor microenvironment-triggered release (Original Report). Angewandte Chemie-International Edition 2021;60:2663-2667. https://doi.org/10.1002/anie.202012956
• Sara El-Sahli, Khang Hua, Andrew Sulaiman, Jason Chambersa, Li Li, Elijah Farah, Dan Liu, Sarah McGarry, Peiyong Zheng, Seung-Hwan Lee, Jiefeng Cui, Marc Ekker, Marceline Cote, Tommy Alain, Xuguang Li, Vanessa D’Costa, Lisheng Wang^@ and Suresh Gadde^@ (^@corresponding author). A triple-drug nanotherapy to target breast cancer cells, cancer stem cells and tumor vasculature (Original Report). Cell Death & Disease 2020; 12: 8. https://doi.org/10.1038/s41419-020-03308-w
• Shuxin Xu, Lisheng Wang and Zhen Liu. Molecularly Imprinted Polymer Nanoparticles: An Emerging Versatile Platform for Cancer Nanomedicine (Review). Angewandte Chemie- International Edition 2020. https://onlinelibrary.wiley.com/doi/10.1002/anie.202005309

• Shrey Sindhwani^#, Abdullah Muhammad Syed^# (^#equal contribution), Jessica Ngai, Benjamin R. Kingston, Laura Maiorino, Jeremy Rothschild, Presley MacMillan, Yuwei Zhang, Netra Unni, Tran Hoang, Stefan Wilhelm, Anton Zilman, Suresh Gadde, Andrew Sulaiman, Ben Ouyang, Zachary Lin, Lisheng Wang, Mikala Egeblad, Warren C. W. Chan. The entry of nanoparticles into solid tumours? Nature Materials 2020; 19: 566-579.
• Andrew Sulaiman, Sarah McGarry, Sara El-Sahli, Li Li, Jason Chambers, Alexandra Phan, Marceline Côté, Greg O. Cron, Tommy Alain, Yevgeniya Le, Seung-Hwan Lee, Sheng Liu, Daniel Figeys, Suresh Gadde*, Lisheng Wang* (*corresponding authors). Co-Targeting Bulk Tumor and CSCs in Clinically Translatable TNBC Patient-Derived Xenografts via Combination Nanotherapy. Molecular Cancer Therapeutics 2019; 18: 1755–1764. (Highlighted “In recognition of breast cancer awareness for advances in breast cancer therapies that build on a long history of discovery yet demonstrate an accelerating pace of development”).
• Sara El-Sahli, Ying Xie, Lisheng Wang*, Sheng Liu* (*corresponding authors). Wnt Signaling in Cancer Metabolism and Immunity (Invited Review). Cancers 2019; 11: 904.
• Andrew Sulaiman, Sarah McGarry, Xianghui Han, Sheng Liu*, Lisheng Wang* (* corresponding author). CSCs in TNBC - One Size Does Not Fit All: Therapeutic Advances in Targeting Heterogeneous Epithelial and Mesenchymal CSCs (Invited Review). Cancers 2019: 11: 1128.
• Andrew Sulaiman, Sarah McGarry, Li Li, Deyong Jia, Sarah Ooi, Christina Addison, Jim Dimitroulakos, Angel Arnaout, Carolyn Nessim, Zemin Yao, Guang Ji, Haiyan Song, Suresh Gadde, Xuguang Li, Lisheng Wang. Dual inhibition of Wnt and Yes-associated protein signaling retards the growth of triple-snegative breast cancer in both mesenchymal and epithelial states. Molecular Oncology 2018; 12: 423-440.
• Deyong Jia, Li Li, Andrew Sulaiman, David Allan, Xuguang Li, Jonathan Lee, Guang Ji, Zemin Yao, Suresh Gadde, Danial Figeys, Lisheng Wang. An autocrine inflammatory forward-feedback loop after chemotherapy withdrawal facilitates the repopulation of drug-resistant breast cancer cells. Cell Death & Disease 2017; 8, e2932.
• Yuan Tan, Bodour AlKhamees1, Deyong Jia, Li Li, Jean-François Couture, Daniel Figeys, Masahisa Jinushi*, Lisheng Wang * (*corresponding authors). MFG-E8 is critical for embryonic stem cell-mediated T cell immunomodulation. Stem Cell Reports 2015; 5: 741–752.
• Deyong Jia, Weixia Yang, Li Li, Huijuan Liu, Yuan Tan, Sarah Ooi, Lingyi Chi, Lionel G. Filion, Daniel Figeys, Wang L. β-catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death and Differentiation 2015; 22: 298-310.
• Huang T^#, Li L^#, Moalim-Nour L^# (^# equal contribution), Jia D, Jian B, Yao, Z, Bennett S, Figeys D, Wang L. A regulatory network involving β-catenin, E-cadherin, PI3K/Akt, and Slug balances self-renewal and differentiation of human pluripotent stem cells in response to Wnt signaling. Stem Cells 2015; 33:1419-1433. (Selected as one of four research articles for “Stem Cell Awareness 2015” by Chief-Editor based on represent highly cited, cutting-edge stem cell science and solutions to problems currently faced in the field).
• Mohib K, Wang L. Differentiation and characterization of dendritic cells from human embryonic stem cells. Current Protocol in Immunology 2012; Chapter 22:Unit 22F 11
• Tian R^#, Wang S^# (^# equal contribution), Elisma F, Li L, Zhou H, Wang L*, Figeys D* (*correspondence authors). Rare Cell Proteomic Reactor Applied to Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Quantitative Proteomics Study of Human Embryonic Stem Cell Differentiation. Mol Cell Proteomics. 2011; 10(2): M110.000679.
• Li L^#, Wang S^#, Jezierski A^# (^# equal contribution), Moalim-Nour L, Mohib K, Parks RJ, Francesco Retta S, Wang L. A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates self-renewal of human embryonic stem cells. Stem Cells 2010; 28: 247-257 (Top downloaded articles in Stem Cells in February 2010)
• Li L, Wang BH, Wang S, Moalim-Nour L, Mohib K, Lohnes D, Wang L. Individual cell movement, asymmetric colony expansion, Rho-associated kinase and E-cadherin impact the clonogenic assay of human embryonic stem cells. Biophysical Journal 2010; 98: 2442-2551 (Featured article).
• Cerdan C, Bendall SC, Wang L, Stewart M, Werbowetski T, Bhatia M. Complement targeting of nonhuman sialic acid does not mediate cell death of human ESCs. Nature Medicine 2006; 12: 1113-1114.
• Wang L^#, Menendé P^# (^# equal contribution), Shojaei F, Li L, Mazurier F, Dick JE, Cerdan C, Levac K, Bhatia M. Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HoxB4 expression. Journal of Experimental Medicine 2005; 201: 1603-1614
• Wang L, Li L, Menendez P, Cerdan C, Goodale D, Bhatia M. Human embryonic stem cells maintained in the absence of mouse embryonic fibroblasts or conditioned media are capable of hematopoietic development. Blood 2005; 105: 4598-4603.
• Roura-Mir C^#, Wang L^# (^# equal contribution), Cheng TC, Matsunaga I, Dascher C, Peng S, Fenton MJ, Moody DB. M. tuberculosis regulates CD1 antigen presentation pathways through TLR-2. Journal of Immunology 2005; 175:1758-1766.
• Wang L, Li L, Shojaei F, Levac K,Cerdan C,Menendez P, Martin T, Rouleau A, Bhatia M. Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity 2004; 21: 31-41.
• Chadwick K^#, Wang L^# (^#equal contribution), Li L, Menendez P, Murdoch B, Rouleau A, Bhatia M. Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood 2003; 102: 906-915. (Comment) in Blood 2003; 102: 776.
• Kamath A, Wang L, Das H, Lin L, Reinhold VN, Bukowski JF. Tea Drinking Enhances Immunity to Microbial Antigens by Priming gd T Cells in vivo. Proc. Natl. Acad. Sci. U. S. A. 2003; 100: 6009-6014.
• Wang L, Das H, Kamath A, Lin L, Bukowski JF. Human Vg2Vd2 T cells augment Migration-inhibitory factor secretion, and counteract the inhibitory effect of glucocorticoids on IL1- b and TNF- a production. Journal of Immunology 2002; 168: 4889-4896.
• Wang L, Kamath A, Das H, Lin L, Bukowski JF. Antibacterial effect of human V g2V d2 T cells in vivo. Journal of Clinical Investigation 2001; 108: 1349-1357.
• Wang L, Das H, Kamath A, Bukowski JF. Human Vg2Vd2 T cells produce IFN- g and TNF- a with an on/off/on cycling pattern in response to live bacterial products. Journal of Immunology 2001; 167: 6195-6201.
• Das H, Wang L, Kamath A and Bukowski JF. Vg2Vd2 T cell receptor–mediated recognition of aminobisphosphonate. Blood 2001; 98(5): 1616-1618.