Dr. Ronald A. Booth

Biography

Dr. Booth is a certified specialist in Clinical Chemistry and a fellow of the Canadian Academy of Clinical Biochemists.  He is currently a Full Professor in the Department of Pathology and Laboratory Medicine at the University of Ottawa and Clinical Biochemist at the Ottawa Hospital and Eastern Ontario Regional Laboratory Association (EORLA) where he directs the Immunology and Neurobiomarkers Section of the EORLA regional laboratory. He is also the Medical Laboratory Director and/or Clinical Biochemistry consultant for various community hospitals in the Eastern Ontario region.

Clinical research interests include diagnostic immunology and autoimmunity, neurobiomarkers and evidence-based utilization of clinical laboratory biomarkers.

Recent Publications

• Ronald A Booth. Measurement of Neurofilament Light Chain in Cerebrospinal Fluid and Blood.  (2021). CMSC Consensus Statement on Neurofilament Biomarkers in Multiple Sclerosis. International Journal of MS Care, 23(S1), 8-10.
• Brandon Lam, Jesse Junyi Li , Muhammad Mukarram, Marie-Joe Nemnom, Ronald A Booth, Venkatesh Thiruganasambandamoorthy.  Validation of the Ottawa Troponin Pathway.  Australas Emerg Care.  2021 May 5.  doi: 10.1016/j.auec.2021.04.004
• Brandon Lam, Hina Chaudry, Muhammad Mukarram, Marie-Joe Nemnom, Soo-Min Kim, Aline Christelle Ishimwe, Monica Taljaard, Robert S. Beanlands, Ronald Booth, Guy Hebert, Ian Stiell, Venkatesh Thiruganasambandamoorthy.  Diagnostic Utility of Creatine Kinase in Patients Presenting to the Emergency Department with Chest Pain.  University of Ottawa Journal of Medicine. 2021 10(2):47-50
• Simon Thebault, Ronald A Booth, Mark S Freedman.  Blood Neurofilament Light Chain: The Neurologist's Troponin?  Biomedicines. 2020 Nov 21;8(11):523
• Julie LV Shaw, Christopher R McCudden, David A Colantonio, Ronald A Booth, Danny C Lin, Ivan M Blasutig, Thomas Moran, Dana Trofimczuk, Chantal Carriere, Anas Gharra, Cheryl Portelance, Chantal Tremblay, Dianne Dupaul, Nathalie Breton, Merina Angelkovski , Chetan Jariwala, Maureen Embleton, Christine Campbell, Kristina Groulx, Karen Larmour.  Effective interventions to improve the quality of critically high point-of-care glucose meter results.  Pract Lab Med. 2020 Oct 19;22:e00184
• Thiruganasambandamoorthy Venkatesh, McRae Andrew D, Rowe Brian H, Sivilotti Marco L A, Mukarram Muhammad, Nemnom Marie-Joe, Booth Ronald A, Calder Lisa A, Stiell Ian G, Wells George A, Cheng Wei, Taljaard Monica. Does N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope?. Annals of internal medicine 2020 May 19;172(10):648-655.
• Thebault Simon, Lee Hyunwoo, Bose Gauruv, Tessier Daniel, Abdoli Mohammad, Bowman Marjorie, Berard Jason, Walker Lisa, Rush Carolina A, MacLean Heather, Booth Ronald A, Narayanan Sridar, Arnold Douglas L, Tabard-Cossa Vincent, Atkins Harold L, Bar-Or Amit, Freedman Mark S. Neurotoxicity after hematopoietic stem cell transplant in multiple sclerosis. Ann Clin Transl Neurol. 2020 May;7(5):767-775.
• Jacobs JFM, Turner KA, Graziani MS, Frinack JL, Ettore MW, Tate JR, Booth RA, McCudden CR, Keren DF, Delgado JC, Zemtsovskaja G, Fullinfaw RO, Caldini A, de Malmanche T, Katakouzinos K, Burke M, Palladini G, Altinier S, Zaninotto M, Righetti G, Melki MT, Bell S, Willrich MAV.  (2020) An international multi-center serum protein electrophoresis accuracy and M-protein isotyping study. Part II: limit of detection and follow-up of patients with small M-proteins.  Clin Chem Lab Med. Mar 26;58(4):547-559.
• Turner KA, Frinack JL, Ettore MW, Tate JR, Graziani MS, Jacobs JFM, Booth RA, McCudden CR, Keren DF, Delgado JC, Zemtsovskaja G, Fullinfaw RO, Caldini A, de Malmanche T, Katakouzinos K, Burke M, Palladini G, Altinier S, Zaninotto M, Righetti G, Melki MT, Bell S, Willrich MAV. (2020) An international multicenter serum protein electrophoresis accuracy and M-protein isotyping study.  Part I: factors impacting limit of quantitation of serum protein electrophoresis.  Clin Chem Lab Med. Mar 26;58(4):533-546.
• Thiruganasambandamoorthy V, Stiell IG, Chaudry H, Mukarram M, Booth RA, Toarta C, Hebert G, Beanlands RS, Wells GA, Nemnom MJ, Taljaard M.  (2020)  Use of conventional cardiac troponin assay for diagnosis of non-ST-elevation myocardial infarction: ‘The Ottawa Troponin Pathway’.  PLoS One. Jan 10;15(1):e0226892.
• Daboval T, Ouellet P, Charles F, Booth RA, MacLean G, Roeper R, Racinet C.J  (2019)  Comparisons between umbilical cord biomarkers for newborn hypoxic-ischemic encephalopathy. Maternal Fetal Neonatal Med. Nov 25:1-14.
• Morrison T, Booth RA, Hauff K, Berardi P, Visram A.  (2019) Laboratory assessment of multiple myeloma.  Adv Clin Chem.89:1-58
• Skeith, L., Abou-Nassar, K. E., Walker, M., Ramsay, T., Booth, R., Wen, S. W., et al. (2018). Are Anti-β2 Glycoprotein 1 Antibodies Associated with Placenta-Mediated Pregnancy Complications? A Nested Case-Control Study. American Journal of Perinatology. 35(11):1093-1099
• Chehroudi, C., Booth, R. A., & Milman, N. (2018). Diagnostic outcome and indications for testing in patients with positive ANCA at a Canadian tertiary care centre. Rheumatology International, 38(4), 641–647.
• Ronald A. Booth, Christopher R. McCudden, Cynthia M. Balion, Ivan M. Blasutig, Ihssan Bouhtiauy, Karina Rodriguez-Capote, Peter Catomeris, Pak Cheung Chan, Yu Chen, Christine Collier, Kristin Hauff, Jawahar Kalra, Dailin Li, Dan C. Lin, Amy H. Lou, Qing H. Meng, Tracy Morrison, Maria D. Pasic, Mabood Qureshi, Ed Randell, Kun-Young Sohn, Vinita Thakur, Dylan Thomas, Andrea Thoni, Cheryl Tomalty, Mohebullah Zamkanei, (2018). Candidate recommendations for protein electrophoresis reporting from the Canadian Society of Clinical Chemists Monoclonal Gammopathy Working Group. Clinical Biochemistry, 51, 10–20.
• McCudden, C. R., Booth, R. A., Lin, D. C. C., McCurdy, A., Rupani, N., & Kew, A. (2018). Synoptic reporting for protein electrophoresis and immunofixation. Clinical Biochemistry, 51, 21–28.
• Mina Salamatmanesh, Christopher R. McCudden, Arleigh McCurdy, Ronald A. Booth. (2018). Monoclonal protein reference change value as determined by gel-based serum protein electrophoresis. Clinical Biochemistry, 51, 61–65. http://doi.org/10.1016/j.clinbiochem.2017.10.006
• David Keren, Christopher R. McCudden, Ronald A. Booth. (2018). Editorial on laboratory diagnosis and management of plasma cell dyscrasias special issue. Clinical Biochemistry, 51, 1–3.
• Booth, R. A., Jiang, Y., Morrison, H., Orpana, H., Rogers Van Katwyk, S., & Lemieux, C. (2017). Ethnic dependent differences in diagnostic accuracy of glycated hemoglobin (HbA1c) in Canadian adults. Diabetes Research and Clinical Practice, 136, 143–149.