Dr. Wandong Zhang

Dr. Wandong Zhang
Dr. Wandong Zhang
Adjunct Professor, Faculty of Medicine, Member, Faculty of Graduate & Post-Doctoral Studies

451 Smyth Road, Ottawa, Ontario, K1H 8M5
613-993-5988 (Telephone)
613-618-6899 (Mobile)

Another E-mail: [email protected]



Terstappen G, Meyer A, Bell R, Zhang W. 2021. Strategies for delivering central nervous system therapeutics across the blood-brain barrier. Nature Review Drug Discovery 2021 Mar 1. doi: 10.1038/s41573-021-00139-y. (https://www.nature.com/articles/s41573-021-00139-y)

Li Y, Terstappen GC, Zhang W. Differentiation of Human Induced Pluripotent Stem Cells (hiPSC) into Endothelial-Type Cells and Establishment of an In Vitro Blood-Brain Barrier Model. Methods Mol Biol. 2021 Mar 11. doi: 10.1007/7651_2021_363. Epub ahead of print. PMID: 33689164.  

Castonguay N, Zhang W. Langlois M-A. 2021. Meta-Analysis of the Dynamics of the Emergence of Genetic Variants of SARS-CoV-2. Frontier in Microbiology Virology (accepted)

Huang JS, Spencer R, Zhang W. 2021. Semi-covariance co-efficiency analysis of spike proteins from SARS-CoV-2 and other coronaviruses for viral evolution and characteristics associated with fatality. Entropy 23(5):512.

Zhang W, Liu QY, Haqqani AS, Leclerc S, Baumann E, Ly D, Delaney CE, Liu Z-Y, Star AT, Brunette E, Fauteux F, Sodja C, Hewitt M, Sandhu JK, Stanimirovic DB. 2020. Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of mouse and human. Fluids Barriers CNS 17:47.

Li Y, Sun XY, Liu HF, Huang L, Meng GF, Ding Y, Su WJ, Lu JQ, Gong XM, Terstappen G, Zhang R, Zhang W. 2019. Development of human in vitro BBB model from iPSC-derived endothelial cells to predict in vivo BBB permeability of CNS drugs. Neuroscience Bulletin 35(6): 996-1010 (PMID: 31079318).

Liu HF, Dong K, Zhang W, Summerfield SG, Terstappen GC. 2018. Prediction of brain-to-blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems. Drug Discovery Today 23(7):1357-1372. (PMID: 29548981)

Gong S, Li Y, Su W-J, Ding Y, Lu J-Q, Dong K, Hood S, Zhang W, Terstappen GC.

2018. Quantitative algorithm-based paired imaging measurement for antibody-triggered endocytosis in cultured cells. SLAS Discovery 23(8): 832-841.

Liu HF, Chen Y, Huang L, Sun XY, Fu TT, Wu SQ, Zhu XY, Zhen W, Liu K, Lu G, Cai W, Yang T, Zhang W, Yu XY, Wan ZH, Wang JF, Summerfield S, Dong K, Terstappen GC. 2018. Drug distribution into the peripheral nerve. J. Pharmacol. Exp. Ther. 365(2): 336-345. doi: 10.1124/jpet.117.245613 (PMID: 29511033).

Li X, Zhu X, Zhang W, et al. 2018. The etiological effect of a new low-frequency ESR1 variant on Mild Cognitive Impairment and Alzheimer's Disease: a population-based study. Aging (Albany NY). 10(9): 2316-2337. (PMID: 30222591. DOI: 101548)

Bamji-Mirza M, Li Y, Najem D, Liu QY, Stupak J, Chen K, Li J, Walker D, Lue L-F, Yang Z, Rogaeva E, Zhang W. 2018. Genetic variations in ABCA7 can increase secreted levels of Aβ1-42 and ABCA7 transcription in cell culture models. J. Alzheimer’s Disease. 66: 853-854 (Erratum) (PMID: 30400101)

Dorey E, Bamji-Mirza M, Najem D, Li Y, Liu H, Callaghan D, Walker D, Lue L-H, Stanimirovic D, Zhang W. 2017. Apolipoprotein E isoforms differentially regulate Alzheimer’s and Aβ-induced inflammatory response in vivo and in vitro. J. Alzheimer’s Disease 57: 1265-1279. (PMID: 28372324). 

Liu H, Huang L, Li Y, Fu T, Sun X, Zhang Y-Y, Gao R, Chen Q, Zhang W, Sahi J, Summerfield S, Dong K. 2017. Correlation between membrane protein expression levels and transcellular transport activity for breast cancer resistance protein (BCRP). Drug Metabolism & Disposition 45(5):449-456. doi: 10.1124/dmd.116.074245. (PMID: 28209803)

Zhen W, Liu A-L, Lu J-Q, Zhang W, Tattersall D, Wang J-F. 2017. An alternative cuprizone-induced demyelination and remyelination mouse model.  ASN Neuro 2017; 9(4):1759091417725174. (PMID: 28840755)

Bamji-Mirza M, Li Y, Najem D, Liu QY, Stupak J, Chen K, Li J, Walker D, Lue L-F, Yang Z, Rogaeva E, Zhang W. 2016. Genetic variations in ABCA7 can increase secreted levels of Aβ1-42 and ABCA7 transcription in cell culture models. J. Alzheimer’s Disease. 53: 875-892. (PMID: 27314524). 

Najem D, Bamji-Mirza M, Yang Z, Zhang W. 2016. Characterization of Aβ-induced insulin resistance and the effects of insulin on cholesterol synthesis pathway and Aβ secretion in neural cells. Neuroscience Bulletin 32(3):227-238. (PMID: 27207326).

Zhang W, Bamji-Mirza M, Chang N, Haqqani A, Stanimirovic DB. 2015. Expression and Function of ABC Transporters at the Blood-Brain Barrier. In. The Blood-Brain Barrier in Health and Disease (Volume one)pp. 172-214. Ed. K. Dorovini-Zis, CRC press/Taylor & Francis Group, New York (Corresponding author).

Zhang W, Hou S-T, Stanimirovic DB. 2015. Blood-brain barrier protection in stroke: Taming tPA. In. The Blood-Brain Barrier in Health and Disease (Volume two), pp. 226-246, Ed. K. Dorovini-Zis, CRC press/Taylor & Francis Group, New York.

Research interests

  • Molecular mechanisms of the blood-brain barrier (BBB) ATP-binding cassette (ABC) transporters and stem cells and blood-brain barrier modeling
  • Drug delivery into the brain biotranslational sciences
  • Pathogenesis of neurodegenerative diseases including Alzheimer's disease vascular dementia and stroke
  • Signaling mechanisms of innate immunity and inflammation
  • Viruses and human diseases
  • Neurobiology of neurodegenerative diseases and biotherapeutics