The Host-Microbe Interaction lab is interested in understanding the interplay established between bacteria and their host during infection. We are currently focusing on the enteropathogen Shigella flexneri, which use a Type Three Secretion Apparatus (T3SA) to inject some of its proteins inside human intestinal cells. Our main interests are: 1) T3SA functioning and regulation; 2) bacterial strategies for hijacking the biological processes of the host; 3) bacterial and host adaptation at play during infection. Our long-term objective is to identify novel therapeutic avenues to treat infectious diseases.
- Arena ET*, Campbell-Valois FX*, Tinevez JY*, Nigro G*, Sachse M, Moya-Nilges M, Nothelfer K, Marteyn B, Shorte SL, Sansonetti PJ. Bioimage analysis of Shigella infection reveals targeting of colonic crypts. Proc. Natl. Acad. Sci. USA. 2015 Jun 23; 112(25):E3282-90. doi: 10.1073/pnas.1509091112. *These authors contributed equally.
- Campbell-Valois FX, Sachse M, Sansonetti PJ, Parsot C. Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA. MBio. 2015 May 26; 6(3):e02567-14. doi: 10.1128/mBio.02567-14.
- Campbell-Valois FX, Sansonetti PJ. Tracking bacterial pathogens with genetically-encoded reporters. FEBS Lett. 2014 Aug 1;588(15):2428-36. doi: 10.1016/j.febslet.2014.05.022.
- Campbell-Valois FX, Schnupf P, Nigro G, Sachse M, Sansonetti PJ, Parsot C. A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread. Cell Host Microbe. 2014 Feb 12;15(2):177-89. doi: 10.1016/j.chom.2014.01.005.
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