Dr. Laneuville conducts research on the molecular mechanisms involved in physical inactivity and joint mobility restrictions.
She combines high throughput sequencing methods and functional analyses to characterize gene expression in experimental and human models.
Her main objectives are: to develop experimental models for understanding molecular mechanisms involved; and to apply findings to restore mobility and joint movement to its natural range of motion.
Selected publications
- Knee joint stiffness following immobilization and remobilization: A study in the rat model. Zhou H, Trudel G, Goudreau L, Laneuville O. J Biomech. 2020 Jan 23;99:109471.
- Marrow adipose tissue gradient is preserved through high protein diet and bed rest. A randomized crossover study. Trudel G, Melkus G, Sheikh A, Ramsay T, Laneuville O. Bone Rep. 2019 Oct 31;11:100229.
- Adipocyte hyperplasia: the primary mechanism of supraspinatus intramuscular fat accumulation after a complete rotator cuff tendon tear: a study in the rabbit. Trudel G, Uhthoff HK, Wong K, Dupuis J, Laneuville O. Adipocyte. 2019 Dec;8(1):144-153.
- Imaging of the rabbit supraspinatus enthesis at 7 Tesla: a 4-week time course after repair surgery and effect of channeling. Trudel G, Melkus G, Cron GO, Louati H, Sheikh A, Larson PEZ, Schweitzer M, Lapner P, Uhthoff HK, Laneuville O. J Magn Reson Imaging. 2017 Aug;46(2):461-467.
- Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model. Wong K, Trudel G, Laneuville O. Drug Des Devel Ther. 2017 Dec 21;12:15-24.