The Chica Lab specializes in protein engineering and computational protein design. Our three general aims are (1) to create useful proteins for chemical and biological applications, (2) to develop new computational methods to more efficiently engineer proteins, and (3) to gain fundamental knowledge about the determinants of protein function using a design-based approach instead of the traditional perturbation-based approach. Specifically, we are developing designer biocatalysts for asymmetric synthesis of unnatural amino acids as well as improved red fluorescent proteins for imaging and biosensing applications. We also develop state-of-the-art multistate computational protein design methods to enable the rational design of complex protein functions on demand. More information about our current projects can be found here:http://mysite.science.uottawa.ca/rchica/
The Chica lab supervises students from the Chemistry graduate program.
Lab website: http://mysite.science.uottawa.ca/rchica/