We empower scientists with the latest and the greatest hardware tools for the development of next-generation continuous reactor platforms and sustainable manufacturing processes.

Overview

The Flow Research Facility was founded by Prof. Michael Organ, the director of CCRI, in 2016 to facilitate research at the University of Ottawa and beyond with a state-of-the-art infrastructure for continuous manufacturing and analysis. In 2018, Dr. Debasis Mallik joined the facility as the Flow Research Facility Manager. The research activity at the facility has grown substantially over the last six years, initially serving members of the Science and Engineering faculties of the university, to eventually forming  collaborations with universities across Canada and industries around the world.

What we do and why: Our mission

Continuous manufacturing, an emerging manufacturing platform that relies on the fundamentals of flow chemistry, enables process scientists to make essential commodities on-demand using greener and safer manufacturing methods. The ability to produce chemicals on-demand eliminates unnecessary over-stocking of commodities. The implementation of the Lean and Six Sigma principles through continuous manufacturing can drastically cut down on waste as well as streamline process workflow. However, the initial investment in setting up a process development infrastructure and the lack of technical know-how continue to deter process scientists from embracing the flow format.

The success from a continuous manufacturing process heavily relies on the synchronicity of a rather large cluster of moving parts that must channel reactive fluids in the right direction at the right time in order to achieve the best possible outcome. Our strategy is to identify the 'missing links' in the operation of such a highly synchronous and complex equipment cluster, and develop necessary tools and the core expertise here in Canada. The mission of the Flow Research Facility at the University of Ottawa is to empower scientists with the latest and the greatest hardware tools for the development of next-generation continuous reactor platforms and sustainable manufacturing processes.

We understand that perfection can be hard to attain. But if we make smarter tools and apply them to their fullest capabilities, excellence can be achieved.

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Global collaborators

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Strategic partnerships

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Recent services

Supporting continuous manufacturing research and education at uOttawa and beyond

The Flow Research Facility has grown substantially over the last six years, initially serving members of the uOttawa faculties, to collaborating with other universities across Canada and industries around the world.

The facility played an instrumental role in designing new devices, prototyping such devices in partnership with leading instrument manufacturers around the world, and working with the university faculty members toward authoring key publications. Many of the devices designed at the facility are shown to play key roles as a process analytical technology (PAT), an essential component of continuous manufacturing and continuous process validation (CPV). The facility is equipped with state-of-the-art reaction, sampling, and analysis tools for process intensification, process monitoring, and process validation.

Support and services

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Intensification

Work with chemistry and chemical engineering experts of the university for process intensification using state-of-the-art intensification tools

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Analysis

Bridging gaps between process and analysis using state-of-the-art PAT tool for offline, inline, online, and at-line process monitoring

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Validation

Transforming online sampling and analysis PAT for reliable RTRT

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Branding

Working with strategic partners to deliver complete process solutions at various TRLs across academia and industries

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Training

Building awareness of continuous manufacturing and PAT in scientific community through online and onsite workshops and courses

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Collaboration

Fostering research initiatives between academia and industries in Canada and beyond

Recent headlines

two chromatograms, one with the expected set of peaks from the reagent and the product, and the second one with additional impurity peaks

High-throughput multi-attribute process intensification

The things we think and do not say: Revisiting Liquid Chromatography as a flow manufacturing PAT
Schematic for the uOttawa COVID test ingredient production line

Solving a supply chain issue

Solving a supply chain issue: An inspiring academia/industry partnership story
The space-time reactor showing a sampling valve that allows sampling from various points of the flow tube

Dialing back the chronological clock: Redefining the possible

The Space-Time Reactor: A perspective on correcting the course of a reaction 'retroactively'

Contact us

Flow Chemistry Core Facility

Debasis Mallik
Lead Specialist and Flow Chemistry Manager
Telephone: (613) 562-5800, ext. 6353
[email protected]