The purpose of our lab’s research is to develop new therapies for neurodegenerative disease. Research focuses on discovery (what is going wrong at the level of membrane?), target (how do these lipid changes affect integral membrane protein function?), diagnostics (are circulating lipids in patients biomarkers of neurodegenerative disease progression?) and therapeutics (can existing drugs and new plant-derived compounds be repurposed to treat neurodegenerative disease?).We use super-resolution imaging (stimulated emission depletion STED), liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS), induced pluripotent stem cell technology, mouse models of epileptic seizure, stroke, and Alzheimer Disease, and transgenic engineering technologies to understand molecular mechanisms of brain cell injury and brain repair. We are developing new bioinformatic tools for lipidomic application. We apply a lipidomics approach to cell culture, animal models of disease, and clinical brain and plasma samples to identify biomarkers of disease progression and therapeutic efficacy. We work to identify and repurpose existing drugs and plant-derived traditional medicines that alter lipid composition to effect neurological recovery. We believe that research matters and can improve the quality of life of persons suffering from intractable neurological disorders
The Bennett lab supervises students from graduate programs in Biochemistry, Human Molecular Genetics and Neuroscience, as well as from Biology, Biomedical Engineering, and Chemistry in collaboration as co-supervisor.
Lab website: https://www.med.uottawa.ca/lipidomics/