OISB core facilities
X-ray Crystallography Core Facility
This facility contains a crystallization robot for the high throughput crystallization of biological macromolecules, including DNA, RNA and proteins. In addition, the core has a Rigaku MicroMAX 007-HF for structure resolution equipped with a RAXIS-4 Detector.
Bioinformatics Core Facility
We provide advice on bioinformatics research design, conduct bioinformatics analysis, provide data warehousing services and provide support for grant proposals that involve bioinformatics (including conducting pilot studies, support/collaboration letters, methodological text and more).
Metabolomics Core Facility
Our Metabolomics Core Facility is part of MIRGOV, the Metabolomics Innovation Resource of the Goodman Cancer Research Centre (GCRC), the University of Ottawa and the Van Andel Research Institute (VARI). We house state-of-the-art mass spectrometers for targeted quantification of small molecules, untargeted metabolomics and stable isotope tracing analyses.
This facility contains state-of-the-art infrastructure to study protein structures, including AKTA purification systems combined with size-exclusion columns, a calorimeter for the measurement of protein-ligand thermodynamics and spectrophotomers for the study of protein secondary structures in solution. This facility also includes a crystallization robot to carry out crystallization trials with high throughput capabilities.
India Taylor Lipidomics Research Platform
The was established in 2015 in memory of Ms India Taylor’s fight against spinal muscular atrophy with progressive myoclonic epilepsy, a rare lipid neurodegenerative disorder. Developed with the generous support of private donations to the India Taylor Donation fund, the uOttawa Brain and Mind Institute, Partners Investing in Parkinson’s Research, and Canadian Foundation Innovation (CFI) grants (CFI#16065 and CFI#23890), the research platform is open for both collaborative investigations at cost and fee for service. The platform is directed by Dr Steffany Bennett and managed by Mr Graeme Taylor.