PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS.Rasool D, Burban A, Sharanek A, Madrigal A, Hu J, Yan K, Qu D, Voss AK, Slack RS, Thomas T, Bonni A, Picketts DJ, Soleimani VD, Najafabadi HS, Jahani-Asl A. EMBO Rep. 2024 Mar 1. doi: 10.1038/s44319-024-00082-0. Online ahead of print.PMID: 38429579
CIAO1 and MMS19 deficiency: a lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders.van Karnebeek CDM, Tarailo-Graovac M, Leen R, Meinsma R, Correard S, Jansen-Meijer J, Prykhozhij SV, Pena IA, Ban K, Schock S, Saxena V, Pras-Raves ML, Drögemöller BI, Grootemaat AE, van der Wel NN, Dobritzsch D, Roseboom W, Schomakers BV, Jaspers YRJ, Zoetekouw L, Roelofsen J, Ferreira CR, van der Lee R, Ross CJ, Kochan J, McIntyre RL, van Klinken JB, van Weeghel M, Kramer G, Weschke B, Labrune P, Willemsen MA, Riva D, Garavaglia B, Moeschler JB, Filiano JJ, Ekker M, Berman JN, Dyment D, Vaz FM, Wassermann WW, Houtkooper RH, van Kuilenburg ABP.Genet Med. 2024 Feb 24:101104. doi: 10.1016/j.gim.2024.101104. Online ahead of print.PMID: 38411040
MicroRNA205: A Key Regulator of Cardiomyocyte Transition from Proliferative to Hypertrophic Growth in the Neonatal Heart.Weldrick JJ, Yi R, Megeney LA, Burgon PG.Int J Mol Sci. 2024 Feb 12;25(4):2206. doi: 10.3390/ijms25042206.PMID: 38396885
Optic atrophy 1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1.Triolo M, Baker N, Agarwal S, Larionov N, Podinić T, Khacho M.iScience. 2024 Feb 9;27(3):109164. doi: 10.1016/j.isci.2024.109164. eCollection 2024 Mar 15.PMID: 38414856
The SMC5/6 complex: folding chromosomes back into shape when genomes take a break.Roy S, Adhikary H, D'Amours D.Nucleic Acids Res. 2024 Feb 20:gkae103. doi: 10.1093/nar/gkae103. Online ahead of print.PMID: 38375830
The Complexities of Intestinal Lipoprotein Production in Insulin Resistance and Diabetes: Revisiting a 2010 Diabetes Classic by Pavlic et al.Lewis GF, Mulvihill EE.Diabetes. 2024 Mar 1;73(3):335-337. doi: 10.2337/dbi23-0036.PMID: 38377446
p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress.Lewis K, La Selva R, Maldonado E, Annis MG, Najyb O, Cepeda Cañedo E, Totten S, Hébert S, Sabourin V, Mirabelli C, Ciccolini E, Lehuédé C, Choinière L, Russo M, Avizonis D, Park M, St-Pierre J, Kleinman CL, Siegel PM, Ursini-Siegel J.Redox Biol. 2024 Jan 5;70:103028. doi: 10.1016/j.redox.2024.103028. Online ahead of print.PMID: 38211442
Empirical Bayes single nucleotide variant-calling for next-generation sequencing data.Karimnezhad A, Perkins TJ.Sci Rep. 2024 Jan 18;14(1):1550. doi: 10.1038/s41598-024-51958-z.PMID: 38233494
The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice.Hoyeck MP, Angela Ching ME, Basu L, van Allen K, Palaniyandi J, Perera I, Poleo-Giordani E, Hanson AA, Ghorbani P, Fullerton MD, Bruin JE.Mol Metab. 2024 Feb 2;81:101893. doi: 10.1016/j.molmet.2024.101893. Online ahead of print.PMID: 38309623
NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens.Rodriguez GM, Yakubovich E, Murshed H, Maranda V, Galpin KJC, Cudmore A, Hanna AMR, Macdonald E, Ramesh S, Garson K, Vanderhyden BC.Front Immunol. 2024 Jan 3;14:1295208. doi: 10.3389/fimmu.2023.1295208. eCollection 2023.PMID: 38235131
Wnt7a is Required for Regeneration of Dystrophic Skeletal Muscle.Gurriaran-Rodriguez U, Kodippili K, Datzkiw D, Javandoost E, Xiao F, Rejas MT, Rudnicki MA.bioRxiv. 2024 Jan 25:2024.01.24.577041. doi: 10.1101/2024.01.24.577041. Preprint.PMID: 38328077
Sialyl LewisX glycomimetics bearing an extended anionic chain targeting E- and P- selectin binding sites.Belouin A, Simard RD, Joyal M, Maharsy W, Lau A, Prévost M, Nemer M, Guindon Y.Bioorg Med Chem. 2023 Dec 9;98:117553. doi: 10.1016/j.bmc.2023.117553. Online ahead of print.PMID: 38128297
FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models.Galpin KJC, Rodriguez GM, Maranda V, Cook DP, Macdonald E, Murshed H, Zhao S, McCloskey CW, Chruscinski A, Levy GA, Ardolino M, Vanderhyden BC.Sci Rep. 2024 Jan 8;14(1):787. doi: 10.1038/s41598-024-51217-1.PMID: 38191799
Sox10-Deficient Drug-Resistant Melanoma Cells Are Refractory to Oncolytic RNA Viruses.Abou-Hamad J, Hodgins JJ, Yakubovich E, Vanderhyden BC, Ardolino M, Sabourin LA.Cells. 2023 Dec 29;13(1):73. doi: 10.3390/cells13010073.PMID: 38201278
Accessory subunit NDUFB4 participates in mitochondrial complex I supercomplex formation - ScienceDirectParmar G, Fong-McMaster C, Pileggi C, Patten DA, Cuillerier A, Myers S, Wang Y, Hekimi S, Cuperlovic-Culf M, Harper M-E. Journal of Biological Chemistry 2024. 105626
Mesenchymal ovarian cancer cells promote CD8+ T cell exhaustion through the LGALS3-LAG3 axis.Yakubovich E, Cook DP, Rodriguez GM, Vanderhyden BC.NPJ Syst Biol Appl. 2023 Dec 12;9(1):61. doi: 10.1038/s41540-023-00322-4.PMID: 38086828
Unveiling the Immunogenicity of Ovarian Tumors as the Crucial Catalyst for Therapeutic Success.Rodriguez GM, Yakubovich E, Vanderhyden BC.Cancers (Basel). 2023 Dec 2;15(23):5694. doi: 10.3390/cancers15235694.PMID: 38067396
High-Pressure Delivery of Oncolytic Viruses via Needle-Free Injection Preserves Therapeutic Activity.Said A, Hoang HD, Earl N, Xiang X, Siddiqui N, Côté M, Alain T.Cancers (Basel). 2023 Nov 30;15(23):5655. doi: 10.3390/cancers15235655.PMID: 38067359
The microbiome of two strategies for ammonia removal with the sequencing batch moving bed biofilm reactor treating cheese production wastewater.Tsitouras A, Al-Ghussain N, Butcher J, Stintzi A, Delatolla R.Appl Environ Microbiol. 2023 Nov 27:e0150723. doi: 10.1128/aem.01507-23. Online ahead of print.PMID: 38009922
BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy.Farokhi Boroujeni S, Rodriguez G, Galpin K, Yakubovich E, Murshed H, Ibrahim D, Asif S, Vanderhyden BC.J Ovarian Res. 2023 Nov 28;16(1):231. doi: 10.1186/s13048-023-01313-z.PMID: 38017453
CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy.Stouth DW, vanLieshout TL, Mikhail AI, Ng SY, Raziee R, Edgett BA, Vasam G, Webb EK, Gilotra KS, Markou M, Pineda HC, Bettencourt-Mora BG, Noor H, Moll Z, Bittner ME, Gurd BJ, Menzies KJ, Ljubicic V.Autophagy. 2023 Nov 29. doi:
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.Pileggi CA, Parmar G, Elkhatib H, Stewart CM, Alecu I, Côté M, Bennett SAL, Sandhu JK, Cuperlovic-Culf M, Harper ME.Curr Res Neurobiol. 2023 Oct 6;5:100112. doi: 10.1016/j.crneur.2023.100112. eCollection 2023.PMID: 38020812
Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice.Day EA, Townsend LK, Rehal S, Batchuluun B, Wang D, Morrow MR, Lu R, Lundenberg L, Lu JH, Desjardins EM, Smith TKT, Raphenya AR, McArthur AG, Fullerton MD, Steinberg GR.iScience. 2023 Oct 20;26(11):108269. doi: 10.1016/j.isci.2023.108269. eCollection 2023 Nov 17.PMID: 38026185
Extracellular vesicle storm during the course of Ebola virus infection in primates.Vucetic A, Lafleur A, Côté M, Kobasa D, Chan M, Alvarez F, Piccirillo C, Dong G, Olivier M.Front Cell Infect Microbiol. 2023 Nov 15;13:1275277. doi: 10.3389/fcimb.2023.1275277. eCollection 2023.PMID: 38035334
CLIC1 regulation of cancer stem cells in glioblastoma.Randhawa K, Jahani-Asl A.Curr Top Membr. 2023;92:99-123. doi: 10.1016/bs.ctm.2023.09.004. Epub 2023 Sep 29.PMID: 38007271
A clinically relevant large-scale biomanufacturing workflow to produce natural killer cells and natural killer cell-derived extracellular vesicles for cancer immunotherapy.St-Denis-Bissonnette F, Cummings SE, Qiu S, Stalker A, Muradia G, Mehic J, Mediratta K, Kaczmarek S, Burger D, Lee SH, Wang L, Lavoie JR.J Extracell Vesicles. 2023 Dec;12(12):e12387. doi: 10.1002/jev2.12387.PMID: 38054534
Editorial: Reviews and advances in our understanding of the relationship between the cell cycle, DNA damage and cancer.D'Amours D.Front Cell Dev Biol. 2023 Nov 16;11:1333628. doi: 10.3389/fcell.2023.1333628. eCollection 2023.PMID: 38046669
Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancer. Cook DP, Galpin KJC, Rodriguez GM, Shakfa N, Wilson-Sanchez J, Echaibi M, Pereira M, Matuszewska K, Haagsma J, Murshed H, Cudmore AO, MacDonald E, Tone A, Shepherd TG, Petrik JJ, Koti M, Vanderhyden BC. Commun Biol. 2023 Nov 13;6(1):1152. doi: 10.1038/s42003-023-05529-z.PMID: 37957414
Tissue-Specific Tumour Suppressor and Oncogenic Activities of the Polycomb-like Protein MTF2.Ngubo M, Moradi F, Ito CY, Stanford WL.Genes (Basel). 2023 Sep 27;14(10):1879. doi: 10.3390/genes14101879.PMID: 37895228
The Expression Kinetics and Immunogenicity of Lipid Nanoparticles Delivering Plasmid DNA and mRNA in MiceZhang W, Pfeifle A, Lansdell C, Frahm G, Cecillon J, Tamming L, Gravel C, Gao J, Thulasi Raman SN, Wang L, Sauve S, Rosu-Myles M, Li X, Johnston MJW.Vaccines (Basel). 2023 Oct 11;11(10):1580. doi: 10.3390/vaccines11101580.PMID: 37896985
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energeticsChantal A. Pileggi a b c, Gaganvir Parmar a b, Hussein Elkhatib a b, Corina M. Stewart a b d, Irina Alecu a b e, Marceline Côté a b f, Steffany A.L. Bennett a b e, Jagdeep K. Sandhu a b f g, Miroslava Cuperlovic-Culf a b c 1, Mary-Ellen Harper a b f 1. Received 14 March 2023, Revised 21 August 2023, Accepted 25 September 2023, Available online 6 October 2023, Version of Record 14 October 2023. https://doi.org/10.1016/j.crneur.2023.100112
The Potential of Hormonal Therapies for Treatment of Triple-Negative Breast Cancer.Kirkby M, Popatia AM, Lavoie JR, Wang L.Cancers (Basel). 2023 Sep 24;15(19):4702. doi: 10.3390/cancers15194702.PMID: 37835396
A comparison of rat models that best mimic immune-driven preeclampsia in humans.Jahan F, Vasam G, Cariaco Y, Nik-Akhtar A, Green A, Menzies KJ, Bainbridge SA.Front Endocrinol (Lausanne). 2023 Sep 28;14:1219205. doi: 10.3389/fendo.2023.1219205. eCollection 2023.PMID: 37842294
Staufen1 controls mitochondrial metabolism via HIF2α in embryonal rhabdomyosarcoma and promotes tumorigenesis.Almasi S, SarmastiEmami S, Baird S, Ning Z, Figeys D, Côté J, Cowan KN, Jasmin BJ.Cell Mol Life Sci. 2023 Oct 17;80(11):328. doi: 10.1007/s00018-023-04969-4.PMID: 37847286
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages.Kim H, Aliar K, Tharmapalan P, McCloskey CW, Kuttanamkuzhi A, Grünwald BT, Palomero L, Mahendralingam MJ, Waas M, Mer AS, Elliott MJ, Zhang B, Al-Zahrani KN, Langille ER, Parsons M, Narala S, Hofer S, Waterhouse PD, Hakem R, Haibe-Kains B, Kislinger T, Schramek D, Cescon DW, Pujana MA, Berman HK, Khokha R.
Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation.Susser LI, Nguyen MA, Geoffrion M, Emerton C, Ouimet M, Khacho M, Rayner KJ.Mol Cell Biol. 2023;43(10):531-546. doi: 10.1080/10985549.2023.2253131. Epub 2023 Oct 11.PMID: 37807652
A Markov constraint to uniquely identify elementary flux mode weights in unimolecular metabolic networksChitpin JG, Perkins TJ.J Theor Biol. 2023 Oct 5:111632. doi: 10.1016/j.jtbi.2023.111632. Online ahead of print.PMID: 37804942
Spatiotemporal modeling of chemoresistance evolution in breast tumors uncovers dependencies on SLC38A7 and SLC46A1. Audet-Delage Y, St-Louis C, Minarrieta L, McGuirk S, Kurreal I, Annis MG, Mer AS, Siegel PM, St-Pierre J. Cell Rep. 2023 Oct 3;42(10):113191. doi: 10.1016/j.celrep.2023.113191. Online ahead of print.PMID: 37792528
Pevonedistat, a First in-class NEDD8-activating Enzyme Inhibitor, sensitizes cancer cells to VSVΔ51 Oncolytic Virotherapy.Wong B, Bergeron A, Maznyi G, Ng K, Jirovec A, Birdi HK, Serrano D, Spinelli M, Thomson M, Taha Z, Alwithenani A, Chen A, Lorimer I, Vanderhyden B, Arulanandam R, Diallo JS.Mol Ther. 2023 Sep 27:S1525-0016(23)00504-X. doi: 10.1016/j.ymthe.2023.09.017. Online ahead of print.PMID: 37766429
Humoral Responses Elicited after a Fifth Dose of SARS-CoV-2 mRNA Bivalent Vaccine.Tauzin A, Beaudoin-Bussières G, Benlarbi M, Nayrac M, Bo Y, Gendron-Lepage G, Medjahed H, Perreault J, Gokool L, Arlotto P, Morrisseau C, Tremblay C, Kaufmann DE, Martel-Laferrière V, Levade I, Côté M, Bazin R, Finzi A.
Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection.Ghorbani P, Kim SY, Smith TKT, Minarrieta L, Robert-Gostlin V, Kilgour MK, Ilijevska M, Alecu I, Snider SA, Margison KD, Nunes JRC, Woo D, Pember C, O'Dwyer C, Ouellette J, Kotchetkov P, St-Pierre J, Bennett SAL, Lacoste B, Blais A, Nair MG, Fullerton MD.PLoS Pathog. 2023 Sep 25;19(9):e1011658. doi: 10.1371/journal.ppat.1011658. Online ahead of print.PMID: 37747879
A Versatile Strategy for Genetic Manipulation of Cajal-Retzius Cells in the Adult Mouse Hippocampus.van Bruggen R, Patel ZH, Wang M, Suk TR, Rousseaux MWC, Tan Q.eNeuro. 2023 Sep 29:ENEURO.0054-23.2023. doi: 10.1523/ENEURO.0054-23.2023. Online ahead of print.PMID: 37775311
KIT D816V is dimerization-independent and activates downstream pathways frequently perturbed in mastocytosis. Rajan V, Prykhozhij SV, Pandey A, Cohen AM, Rainey JK, Berman JN. Br J Haematol. 2023 Sep;202(5):960-970. doi: 10.1111/bjh.18116. Epub 2022 Mar 4. PMID: 35245395
Modification of histidine repeat proteins by inorganic polyphosphate.Neville N, Lehotsky K, Yang Z, Klupt KA, Denoncourt A, Downey M, Jia Z.Cell Rep. 2023 Sep 1;42(9):113082. doi: 10.1016/j.celrep.2023.113082. Online ahead of print.PMID: 37660293
Mutation Knock-in Methods Using Single-Stranded DNA and Gene Editing Tools in Zebrafish.Prykhozhij SV, Berman JN.Methods Mol Biol. 2024;2707:279-303. doi: 10.1007/978-1-0716-3401-1_19.PMID: 37668920
Radiation induces long-term muscle fibrosis and promotes a fibrotic phenotype in fibro-adipogenic progenitorsNicolas Collao, Donna D'Souza, Laura Messeiller, Evan Pilon, Jessica Lloyd, Jillian Larkin, Matthew Ngu, Alexanne Cuillerier, Alexander E. Green, Keir J. Menzies, Yan Burelle, Michael De LisioFirst published: 06 September 2023 https://doi.org/10.1002/jcsm.13320
MetaPep: A core peptide database for faster human gut metaproteomics database searches.Sun Z, Ning Z, Cheng K, Duan H, Wu Q, Mayne J, Figeys D.Comput Struct Biotechnol J. 2023 Aug 29;21:4228-4237. doi: 10.1016/j.csbj.2023.08.025. eCollection 2023.PMID: 37692080
The Regulation and Immune Signature of Retrotransposons in Cancer. Alkailani MI, Gibbings D.Cancers (Basel). 2023 Aug 30;15(17):4340. doi: 10.3390/cancers15174340.PMID: 37686616
Generation of the human iPSC lines AKOSi011-A carrying the mutation p.Pro65Ser/p.Asp35T and AKOSi012-A, carrying the mutation p.Tyr231His, derived from FAHN patient fibroblasts. Efendic F, Krohn S, Murua Escobar H, Venkateswaran S, Bennett SAL, Hermann A, Frech MJ. Stem Cell Res. 2023 Aug 9;71:103178. doi: 10.1016/j.scr.2023.103178. Online ahead of print. PMID: 37573804
Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic Potential.Lewicky JD, Martel AL, Gupta MR, Roy R, Rodriguez GM, Vanderhyden BC, Le HT.Cancers (Basel). 2023 Aug 16;15(16):4127. doi: 10.3390/cancers15164127.PMID: 37627155
Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates.Brunette S, Sharma A, Bell R, Puente L, Megeney LA.Microb Cell. 2023 Jul 10;10(8):157-169. doi: 10.15698/mic2023.08.801. eCollection 2023 Aug 7.PMID: 37545643
The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis. Khan AUH, Ali AK, Marr B, Jo D, Ahmadvand S, Fong-McMaster C, Almutairi SM, Wang L, Sad S, Harper ME, Lee SH. Cell Mol Immunol. 2023 Aug 9. doi: 10.1038/s41423-023-01071-4. Online ahead of print.PMID: 37553427
Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity.Whytock KL, Pino MF, Sun Y, Yu G, De Carvalho FG, Yeo RX, Vega RB, Gaganvir P, Divoux A, Kapoor N, Yi F, Cornnell HH, Patten DA, Harper ME, Gardell SJ, Smith SR, Walsh MJ, Sparks LM.Am J Physiol Endocrinol Metab. 2023 Aug 16. doi: 10.1152/ajpendo.00143.2023. Online ahead of print.PMID: 37584609
The Influence of Protein Secretomes of Enterococcus durans on ex vivo Human Gut Microbiome.Comerlato CB, Zhang X, Walker K, Mayne J, Figeys D, Brandelli A.Probiotics Antimicrob Proteins. 2023 Aug 17. doi: 10.1007/s12602-023-10136-9. Online ahead of print.PMID: 37589783
Development of a V5-tag-directed nanobody and its implementation as an intracellular biosensor of GPCR signalling. Zeghal M, Matte K, Venes A, Patel S, Laroche G, Sarvan S, Joshi M, Rain JC, Couture JF, Giguère PM.J Biol Chem. 2023 Jul 28:105107. doi: 10.1016/j.jbc.2023.105107. Online ahead of print.PMID: 37517699
Ketone Ester Administration Improves Glycemia in Obese Mice. Tabatabaei Dakhili SA, Yang K, Locatelli CAA, Saed CT, Greenwell AA, Chan JSF, Chahade JJ, Scharff J, Al Imarah S, Eaton F, Crawford PA, Gopal K, Mulvihill EE, Ussher JR.Am J Physiol Cell Physiol. 2023 Aug 14. doi: 10.1152/ajpcell.00300.2023. Online ahead of print.PMID: 37575059
The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.Findlay S, Nair R, Merrill RA, Kaiser Z, Cajelot A, Aryanpour Z, Heath J, St-Louis C, Papadopoli D, Topisirovic I, St-Pierre J, Sebag M, Kesarwala AH, Hulea L, Taylor EB, Shanmugam M, Orthwein A. Blood Adv. 2023 Jul 25;7(14):3485-3500. doi: 10.1182/bloodadvances.2022008345. PMID: 36920785
Synthesis of Sialyl LewisX Mimetics with E- and P-Selectin Binding Properties and Immunosuppressive Activity. Simard RD, Joyal M, Beaugrand T, Gauthier J, Hardine E, Desriac A, Buffet CH, Prévost M, Nemer M, Guindon Y. J Org Chem. 2023 Jul 14. doi: 10.1021/acs.joc.3c00956. Online ahead of print. PMID: 37449872
Deconstructing interindividual variability in energy metabolism: implications for metabolic health.Miles-Chan JL, Harper ME. Am J Physiol Endocrinol Metab. 2023 Aug 1;325(2):E107-E112. doi: 10.1152/ajpendo.00060.2023. Epub 2023 Jun 14. PMID: 37315156
ATF2 orchestrates macrophage differentiation and activation to promote antibacterial responses.Rajabalee N, Siushansian H, Weerapura M, Berton S, Berbatovci F, Hooks B, Geoffrion M, Yang D, Harper ME, Rayner K, Blais A, Sun J.J Leukoc Biol. 2023 Jul 4:qiad076. doi: 10.1093/jleuko/qiad076. Online ahead of print.PMID: 37403209
GDF15 promotes weight loss by enhancing energy expenditure in muscle.Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR.Nature. 2023 Jun 28. doi: 10.1038/s41586-023-06249-4. Online ahead of print.PMID: 37380764
A Recent SARS-CoV-2 Infection Enhances Antibody-Dependent Cellular Cytotoxicity against Several Omicron Subvariants following a Fourth mRNA Vaccine Dose.Beaudoin-Bussières G, Tauzin A, Dionne K, Gendron-Lepage G, Medjahed H, Perreault J, Levade I, Alfadhli L, Bo Y, Bazin R, Côté M, Finzi A.Viruses. 2023 May 29;15(6):1274. doi: 10.3390/v15061274.PMID: 37376574
Tissue-Engineered Disease Modeling of Lymphangioleiomyomatosis Exposes a Therapeutic Vulnerability to HDAC Inhibition.Pietrobon A, Yockell-Lelièvre J, Melong N, Smith LJ, Delaney SP, Azzam N, Xue C, Merwin N, Lian E, Camacho-Magallanes A, Doré C, Musso G, Julian LM, Kristof AS, Tam RY, Berman JN, Shoichet MS, Stanford WL.Adv Sci (Weinh). 2023 Jul 3:e2302611. doi: 10.1002/advs.202302611. Online ahead of print.PMID: 37400371
Revealing proteome-level functional redundancy in the human gut microbiome using ultra-deep metaproteomicsLi L, Wang T, Ning Z, Zhang X, Butcher J, Serrana JM, Simopoulos CMA, Mayne J, Stintzi A, Mack DR, Liu YY, Figeys D. Nat Commun. 2023 Jun 10;14(1):3428. doi: 10.1038/s41467-023-39149-2.PMID: 37301875
Satellite cell contribution to disease pathology in Duchenne muscular dystrophy.Kodippili K, Rudnicki MA.Front Physiol. 2023 May 30;14:1180980. doi: 10.3389/fphys.2023.1180980. eCollection 2023.PMID: 37324396
The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11.Tolbert WD, Chen Y, Sun L, Benlarbi M, Ding S, Manickam R, Pangaro E, Nguyen DN, Gottumukkala S, Côté M, Gonzalez FJ, Finzi A, Tehrani ZR, Sajadi MM, Pazgier M.Front Immunol. 2023 Jun 2;14:1178355. doi: 10.3389/fimmu.2023.1178355. eCollection 2023.PMID: 37334379
Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice.Reid K, Daniels EG, Vasam G, Kamble R, Janssens GE, Hu IM, Green AE, Houtkooper RH, Menzies KJ.Sci Rep. 2023 May 24;13(1):8391. doi: 10.1038/s41598-023-35196-3.PMID: 37225705
Differentiation and single-cell RNA-seq analyses of human pluripotent-stem-cell-derived renal organoids. Lian E, Pietrobon A, Stanford WL.STAR Protoc. 2023 May 22;4(2):102314. doi: 10.1016/j.xpro.2023.102314. Online ahead of print.PMID: 37220001
Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress.Fadzeyeva E, Locatelli CAA, Trzaskalski NA, Nguyen MA, Capozzi ME, Vulesevic B, Morrow NM, Ghorbani P, Hanson AA, Lorenzen-Schmidt I, Doyle MA, Seymour R, Varin EM, Fullerton MD, Campbell JE, Mulvihill EE.iScience. 2023 Apr 26;26(5):106748. doi: 10.1016/j.isci.2023.106748. eCollection 2023 May 19.PMID: 37216093
TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins.Fatica T, Naas T, Liwak U, Slaa H, Souaid M, Frangione B, Kattini R, Gaudreau-Lapierre A, Trinkle-Mulcahy L, Chakraborty P, Holcik M.Genes (Basel). 2023 May 5;14(5):1043. doi: 10.3390/genes14051043.PMID: 37239403
phox2ba: The Potential Genetic Link behind the Overlap in the Symptomatology between CHARGE and Central Congenital Hypoventilation Syndromes.MacLean JE, Wertman JN, Prykhozhij SV, Chedrawe E, Langley S, Steele SL, Ban K, Blake K, Berman JN.Genes (Basel). 2023 May 15;14(5):1086. doi: 10.3390/genes14051086.PMID: 37239446
Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female C57Bl/6J mice fed a Western diet. Nunes JRC, Smith TKT, Ghorbani P, O'Dwyer C, Trzaskalski NA, Dergham H, Pember C, Kilgour MK, Mulvihill EE, Fullerton MD. Am J Physiol Endocrinol Metab. 2023 May 17. doi: 10.1152/ajpendo.00124.2023. Online ahead of print. PMID: 37196059
Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses. Raman SNT, Zetner A, Hashem AM, Patel D, Wu J, Gravel C, Gao J, Zhang W, Pfeifle A, Tamming L, Parikh K, Cao J, Tam R, Safronetz D, Chen W, Johnston MJW, Wang L, Sauve S, Rosu-Myles M, Domselaar GV, Li X. Emerg Microbes Infect. 2023 Dec;12(1):2192821. doi: 10.1080/22221751.2023.2192821. PMID: 36927227
16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice.Béland-Millar A, Kirby A, Truong Y, Ouellette J, Yandiev S, Bouyakdan K, Pileggi C, Naz S, Yin M, Carrier M, Kotchetkov P, St-Pierre MK, Tremblay MÈ, Courchet J, Harper ME, Alquier T, Messier C, Shuhendler AJ, Lacoste B. Cell Rep. 2023 May 6;42(5):112485. doi: 10.1016/j.celrep.2023.112485. Online ahead of print.PMID: 37149866
Signed distance correlation (SiDCo): an online implementation of distance correlation and partial distance correlation for data-driven network analysis. Monti F, Stewart D, Surendra A, Alecu I, Nguyen-Tran T, Bennett SAL, Čuperlović-Culf M. Bioinformatics. 2023 May 3:btad210. doi: 10.1093/bioinformatics/btad210. Online ahead of print. PMID: 3713723
Novel Homozygous Variant in COQ7 in Siblings With Hereditary Motor Neuropathy.Smith IC, Pileggi CA, Wang Y, Kernohan K, Hartley T, McMillan HJ, Sampaio ML, Melkus G, Woulfe J, Parmar G, Bourque PR, Breiner A, Zwicker J, Pringle CE, Jarinova O, Lochmüller H, Dyment DA, Brais B, Boycott KM; Care4Rare Canada Consortium,; Hekimi S, Harper ME, Warman-Chardon J. Neurol Genet. 2023 Jan 25;9(1):e200048. doi: 10.1212/NXG.0000000000200048. eCollection 2023 Feb.
Simultaneous engineering of natural killer cells for CAR transgenesis and CRISPR-Cas9 knockout using retroviral particles.Jo DH, Kaczmarek S, Shin O, Wang L, Cowan J, McComb S, Lee SH. Mol Ther Methods Clin Dev. 2023 Mar 15;29:173-184. doi: 10.1016/j.omtm.2023.03.006. eCollection 2023 Jun 8. PMID: 37063482
Differences in Sex-Specific Frequency of Glucocerebrosidase Variant Carriers and Familial Parkinsonism.Ortega RA, Bressman SB, Raymond D, Ozelius LJ, Wang C, Bennett SAL, Saunders-Pullman R. Mov Disord. 2023 Apr;38(4):714-715. doi: 10.1002/mds.29353. PMID: 37061880
Effects of pair-housing pubertal and adult male and female mice on LPS-induced age-dependent immune responses: A potential role for the gut microbiota.Murray E, Butcher J, May Kearns M, Lamba S, Liang J, Stintzi A, Ismail N. Brain Behav Immun. 2023 May;110:297-309. doi: 10.1016/j.bbi.2023.03.009. Epub 2023 Mar 11. PMID: 36914014
Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the "Lunar Palace 365" experiment.Hao Z, Meng C, Li L, Feng S, Zhu Y, Yang J, Han L, Sun L, Lv W, Figeys D, Liu H.Microbiome. 2023 Apr 24;11(1):88. doi: 10.1186/s40168-023-01506-0.PMID: 37095530
Granulosa cell-derived miR-379-5p regulates macrophage polarization in polycystic ovarian syndrome.Salehi R, Asare-Werehene M, Wyse BA, Abedini A, Pan B, Gutsol A, Jahangiri S, Szaraz P, Burns KD, Vanderhyden B, Li J, Burger D, Librach CL, Tsang BK.Front Immunol. 2023 Mar 24;14:1104550. doi: 10.3389/fimmu.2023.1104550. eCollection 2023.PMID: 37033997
Molecularly Imprinted Nanobeacons Redirect Innate Immune Killing towards Triple Negative Breast Cancer.Guan P, Guo Z, Xu S, Lu H, Wang L, Gu Z, Liu Z. Angew Chem Int Ed Engl. 2023 Apr 17;62(17):e202301202. doi: 10.1002/anie.202301202. Epub 2023 Mar 10. PMID: 36814079
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain.Suk TR, Nguyen TT, Fisk ZA, Mitkovski M, Geertsma HM, Parmasad JA, Heer MM, Callaghan SM, Benseler F, Brose N, Tirard M, Rousseaux MWC.iScience. 2023 Mar 9;26(4):106350. doi: 10.1016/j.isci.2023.106350. eCollection 2023 Apr 21.PMID: 37009224
DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice.Pfeifle A, Thulasi Raman SN, Lansdell C, Zhang W, Tamming L, Cecillon J, Laryea E, Patel D, Wu J, Gravel C, Frahm G, Gao J, Chen W, Chaconas G, Sauve S, Rosu-Myles M, Wang L, Johnston MJW, Li X.Front Immunol. 2023 Mar 16;14:1020134. doi: 10.3389/fimmu.2023.1020134. eCollection 2023.PMID: 37006299
PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation.Gravel SP, Ben Khalifa Y, McGuirk S, St-Louis C, Laurin KM, Lavallée É, Benas D, Desbouis S, Amaral F, D'Amours D, Breton L, Jäger S, St-Pierre J., iScience. 2023 Mar 2;26(4):106314. doi: 10.1016/j.isci.2023.106314. eCollection 2023 Apr 21.PMID: 37009228
Fatty acid transport protein inhibition sensitizes breast and ovarian cancers to oncolytic virus therapy via lipid modulation of the tumor microenvironmentSurendran A, Jamalkhah M, Poutou J, Birtch R, Lawson C, Dave J, Crupi MJF, Mayer J, Taylor V, Petryk J, de Souza CT, Moodie N, Billingsley JL, Austin B, Cormack N, Blamey N, Rezaei R, McCloskey CW, Fekete EEF, Birdi HK, Neault S, Jamieson TR, Wylie B, Tucker S, Azad T, Vanderhyden B, Tai LH, Bell JC, Ilkow CS.Front Immunol. 2023 Mar 10;14:1099459. doi: 10.3389/fimmu.2023.1099459. eCollection 2023.PMID: 36969187
Complexity in Hepatic Insulin Resistance - Unraveling the Role of Ubiquitin-Specific Protease 14 in Protein Homeostasis of Metabolic Transcription Factors. Morrow NM, Mulvihill EE. J Pharmacol Exp Ther. 2023 Apr;385(1):1-4. doi: 10.1124/jpet.122.001517. PMID: 36927510
Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study. Garneau L, Terada T, Mistura M, Mulvihill EE, Reed JL, Aguer C.Physiol Rep. 2023 Mar;11(5):e15634. doi: 10.14814/phy2.15634.PMID: 36905198
Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations. Triolo M, Wade S, Baker N, Khacho M. STAR Protoc. 2023 Feb 9;4(1):102107. doi: 10.1016/j.xpro.2023.102107. Online ahead of print. PMID: 36853728
Humoral Responses against BQ.1.1 Elicited after Breakthrough Infection and SARS-CoV-2 mRNA Vaccination. Tauzin A, Benlarbi M, Medjahed H, Grégoire Y, Perreault J, Gendron-Lepage G, Gokool L, Morrisseau C, Arlotto P, Tremblay C, Kaufmann DE, Martel-Laferrière V, Levade I, Côté M, De Serres G, Bazin R, Finzi A. Vaccines (Basel). 2023 Jan 21;11(2):242. doi: 10.3390/vaccines11020242. PMID: 36851122
Placental Mitochondrial Function and Dysfunction in Preeclampsia. Jahan F, Vasam G, Green AE, Bainbridge SA, Menzies KJ. Int J Mol Sci. 2023 Feb 20;24(4):4177. doi: 10.3390/ijms24044177. PMID: 36835587
Recent Developments in Islet Biology: A Review With Patient Perspectives. Basu L, Bhagat V, Ching MEA, Di Giandomenico A, Dostie S, Greenberg D, Greenberg M, Hahm J, Hilton NZ, Lamb K, Jentz EM, Larsen M, Locatelli CAA, Maloney M, MacGibbon C, Mersali F, Mulchandani CM, Najam A, Singh I, Weisz T, Wong J, Senior PA, Estall JL, Mulvihill EE, Screaton RA; for Diabetes Action Canada and the Canadian Islet Research and Training Network.Can J Diabetes. 2023 Mar;47(2):207-221. doi: 10.1016/j.jcjd.2022.11.003. Epub 2022 Nov 8.PMID: 36481263
Mycobacterium tuberculosis infection triggers epigenetic changes that are enriched in a type I IFN signature. Madden K, El Hamra R, Berton S, Felker J, Alvarez GG, Blais A, Sun J. Microlife. 2023 Feb 6;4:uqad006. doi: 10.1093/femsml/uqad006. eCollection 2023. PMID: 36820061
Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer's disease. Liu Y, Bilen M, McNicoll MM, Harris RA, Fong BC, Iqbal MA, Paul S, Mayne J, Walker K, Wang J, Figeys D, Slack RS. Cell Death Dis. 2023 Feb 18;14(2):138. doi: 10.1038/s41419-023-05650-1.PMID: 36801910
Multiomic spatial analysis reveals a distinct mucosa-associated virome. Yan A, Butcher J, Schramm L, Mack DR, Stintzi A. Gut Microbes. 2023 Jan-Dec;15(1):2177488. doi: 10.1080/19490976.2023.2177488. PMID: 36823020
Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling. Gaudreau-Lapierre A, Klonisch T, Nicolas H, Thanasupawat T, Trinkle-Mulcahy L, Hombach-Klonisch S.Int J Mol Sci. 2023 Feb 20;24(4):4246. doi: 10.3390/ijms24044246.PMID: 36835656
Prenatal low-dose methylmercury exposure causes premature neuronal differentiation and autism-like behaviors in a rodent model.Loan A, Leung JW, Cook DP, Ko C, Vanderhyden BC, Wang J, Chan HM.iScience. 2023 Jan 31;26(3):106093. doi: 10.1016/j.isci.2023.106093. eCollection 2023 Mar 17.PMID: 36843845
Effects of pair-housing pubertal and adult male and female mice on LPS-induced age-dependent immune responses: A potential role for the gut microbiota. Murray E, Butcher J, May Kearns M, Lamba S, Liang J, Stintzi A, Ismail N.Brain Behav Immun. 2023 Mar 11:S0889-1591(23)00066-1. doi: 10.1016/j.bbi.2023.03.009. Online ahead of print.PMID: 36914014
Microbiota-directed biotherapeutics: considerations for quality and functional assessment. Emily Ef FeketeDaniel Figeys Xu Zhang
Proteomics characterization of mitochondrial‐derived vesicles under oxidative stress
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Vtc5 Is Localized to the Vacuole Membrane by the Conserved AP-3 Complex to Regulate Polyphosphate Synthesis in Budding YeastAmanda Bentley-DeSousa, Michael DowneymBio. 2021 Sep-Oct; 12(5): e00994-21. Published online 2021 Sep 21. doi: 10.1128/mBio.00994-21
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Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cellsSabrina Robichaud, Garrett Fairman, Viyashini Vijithakumar, Esther Mak, David P. Cook, Alexander R. Pelletier, Sylvain Huard, Barbara C. Vanderhyden, Daniel Figeys, Mathieu Lavallée-Adam, Kristin Baetz, Mireille Ouimet
Autophagy. 2021; 17(11): 3671–3689. Published online 2021 Feb 26. doi: 10.1080/15548627.2021.1886839PMCID: PMC863232
A yeast chemogenomic screen identifies pathways that modulate adipic acid toxicity
Eugene Fletcher, Kevin Mercurio, Elizabeth A. Walden, Kristin Baetz
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Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy
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Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
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Applications of Extracellular Vesicles in Triple-Negative Breast Cancer
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Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments
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PLoS Pathog. 2021 Jan; 17(1): e1009275. Published online 2021 Jan 29. doi: 10.1371/journal.ppat.1009275PMCID: PMC7875390
Global analysis of Saccharomyces cerevisiae growth in mucin
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Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2Yannick Galipeau, Vinayakumar Siragam, Geneviève Laroche, Erika Marion, Matthew Greig, Michaeline McGuinty, Ronald A Booth, Yves Durocher, Miroslava Cuperlovic-Culf, Steffany A.L. Bennett, Angela M. Crawley, Patrick M. Giguère, Curtis Cooper, Marc-André Langlois
EBioMedicine. 2021 Dec; 74: 103700. Published online 2021 Nov 30. doi: 10.1016/j.ebiom.2021.103700PMCID: PMC8629681
Retraction Note to: Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factorsSabine Wislet-Gendebien, Naomi P. Visanji, Shawn N. Whitehead, Diana Marsilio, Weimin Hou, Daniel Figeys, Paul E. Fraser, Steffany A. L. Bennett, Anurag Tandon
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Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAKXiao Xiang, Stéphanie Langlois, Marie-Eve St-Pierre, Anna Blinder, Philippe Charron, Tyson E. Graber, Stephanie L. Fowler, Stephen D. Baird, Steffany A. L. Bennett, Tommy Alain, Kyle N. Cowan Oncogene. 2021; 40(10): 1868–1883. Published online 2021 Feb 9. doi: 10.1038/s41388-020-01623-2 PMCID: PMC7946643
Serine palmitoyltransferase assembles at ER–mitochondria contact sites
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Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infectionMiroslava Cuperlovic-Culf, Emma L. Cunningham, Hossen Teimoorinia, Anuradha Surendra, Xiaobei Pan, Steffany A. L. Bennett, Mijin Jung, Bernadette McGuiness, Anthony Peter Passmore, David Beverland, Brian D. Green Sci Rep. 2021; 11: 10629. Published online 2021 May 20. doi: 10.1038/s41598-021-90243-1 PMCID: PMC8138024
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Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter
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Skelet Muscle. 2021; 11: 26. Published online 2021 Nov 19. doi: 10.1186/s13395-021-00281-6 PMCID: PMC8607597
Chromatin and transcription factor profiling in rare stem cell populations using CUT&Tag
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Muscle Enriched Lamin Interacting Protein (Mlip) Binds Chromatin and Is Required for Myoblast DifferentiationElmira Ahmady, Alexandre Blais, Patrick G. Burgon
Cells. 2021 Mar; 10(3): 615. Published online 2021 Mar 10. doi: 10.3390/cells10030615 PMCID: PMC7998221
Epigenetic plasticity of erythroid progenitors
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Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulationDaniel C.L. Robinson, Morten Ritso, Geoffrey M. Nelson, Zeinab Mokhtari, Kiran Nakka, Hina Bandukwala, Seth R. Goldman, Peter J. Park, Rémi Mounier, Bénédicte Chazaud, Marjorie Brand, Michael A. Rudnicki, Karen Adelman, F. Jeffrey Dilworth
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Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques
Kevin R. Bewley, Karen Gooch, Kelly M. Thomas, Stephanie Longet, Nathan Wiblin, Laura Hunter, Kin Chan, Phillip Brown, Rebecca A. Russell, Catherine Ho, Gillian Slack, Holly E. Humphries, Leonie Alden, Lauren Allen, Marilyn Aram, Natalie Baker, Emily Brunt, Rebecca Cobb, Susan Fotheringham, Debbie Harris, Chelsea Kennard, Stephanie Leung, Kathryn Ryan, Howard Tolley, Nadina Wand, Andrew White, Laura Sibley, Charlotte Sarfas, Geoff Pearson, Emma Rayner, Xiaochao Xue, Teresa Lambe, Sue Charlton, Sarah Gilbert, Quentin J. Sattentau, Fergus Gleeson, Yper Hall, Simon Funnell, Sally Sharpe, Francisco J. Salguero, Andrew Gorringe, Miles Carroll
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Comparison of SARS-CoV-2 indirect and direct RT-qPCR detection methods
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A multiplexed, next generation sequencing platform for high-throughput detection of SARS-CoV-2
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Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between dosesAlexandra Tauzin, Shang Yu Gong, Guillaume Beaudoin-Bussières, Dani Vézina, Romain Gasser, Lauriane Nault, Lorie Marchitto, Mehdi Benlarbi, Debashree Chatterjee, Manon Nayrac, Annemarie Laumaea, Jérémie Prévost, Marianne Boutin, Gérémy Sannier, Alexandre Nicolas, Catherine Bourassa, Gabrielle Gendron-Lepage, Halima Medjahed, Guillaume Goyette, Yuxia Bo, Josée Perreault, Laurie Gokool, Chantal Morrisseau, Pascale Arlotto, Renée Bazin, Mathieu Dubé, Gaston De Serres, Nicholas Brousseau, Jonathan Richard, Roberta Rovito, Marceline Côté, Cécile Tremblay, Giulia C. Marchetti, Ralf Duerr, Valérie Martel-Laferrière, Daniel E. Kaufmann, Andrés Finzi
Cell Host Microbe. 2022 Jan 12; 30(1): 97–109.e5. Published online 2021 Dec 3. doi: 10.1016/j.chom.2021.12.004 PMCID: PMC8639412
Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of ConcernMadalina Elena Carter-Timofte, Rozanne Arulanandam, Naziia Kurmasheva, Kathy Fu, Geneviève Laroche, Zaid Taha, Demi van der Horst, Lena Cassin, Renée M. van der Sluis, Enrico Palermo, Daniele Di Carlo, David Jacobs, Glib Maznyi, Taha Azad, Ragunath Singaravelu, Fanghui Ren, Anne Louise Hansen, Manja Idorn, Christian K. Holm, Martin R. Jakobsen, Julien van Grevenynghe, John Hiscott, Søren R. Paludan, John C. Bell, Jean Seguin, Luc A. Sabourin, Marceline Côté, Jean-Simon Diallo, Tommy Alain, David Olagnier
ACS Infect Dis. 2021 Oct 18 : acsinfecdis.1c00278. Published online 2021 Oct 18. doi: 10.1021/acsinfecdis.1c00278 PMCID: PMC8547501
Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity
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Virology. 2021 Nov; 563: 134–145. Published online 2021 Sep 11. doi: 10.1016/j.virol.2021.09.001 PMCID: PMC8433594
Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes
Debashree Chatterjee, Alexandra Tauzin, Annemarie Laumaea, Shang Yu Gong, Yuxia Bo, Aurélie Guilbault, Guillaume Goyette, Catherine Bourassa, Gabrielle Gendron-Lepage, Halima Medjahed, Jonathan Richard, Sandrine Moreira, Marceline Côté, Andrés Finzi
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Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concernWenwei Li, Yaozong Chen, Jérémie Prévost, Irfan Ullah, Maolin Lu, Shang Yu Gong, Alexandra Tauzin, Romain Gasser, Dani Vézina, Sai Priya Anand, Guillaume Goyette, Debashree Chaterjee, Shilei Ding, William D. Tolbert, Michael W. Grunst, Yuxia Bo, Shijian Zhang, Jonathan Richard, Fei Zhou, Rick K. Huang, Lothar Esser, Allison Zeher, Marceline Côté, Priti Kumar, Joseph Sodroski, Di Xia, Pradeep D. Uchil, Marzena Pazgier, Andrés Finzi, Walther Mothes
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Interferon-Induced HERC5 Inhibits Ebola Virus Particle Production and Is Antagonized by Ebola GlycoproteinErmela Paparisto, Nina R. Hunt, Daniel S. Labach, Macon D. Coleman, Eric J. Di Gravio, Mackenzie J. Dodge, Nicole J. Friesen, Marceline Côté, Andreas Müller, Thomas Hoenen, Stephen D. Barr
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Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern
Wenwei Li, Yaozong Chen, Jérémie Prévost, Irfan Ullah, Maolin Lu, Shang Yu Gong, Alexandra Tauzin, Romain Gasser, Dani Vézina, Sai Priya Anand, Guillaume Goyette, Debashree Chaterjee, Shilei Ding, William D. Tolbert, Michael W. Grunst, Yuxia Bo, Shijian Zhang, Jonathan Richard, Fei Zhou, Rick K. Huang, Lothar Esser, Allison Zeher, Marceline Côté, Priti Kumar, Joseph Sodroski, Di Xia, Pradeep D. Uchil, Marzena Pazgier, Andrés Finzi, Walther Mothes
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Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic EffectsLynda Rocheleau, Geneviève Laroche, Kathy Fu, Corina M. Stewart, Abdulhamid O. Mohamud, Marceline Côté, Patrick M. Giguère, Marc-André Langlois, Martin Pelchat
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Potential Differences in Cleavage of the S Protein and Type 1 Interferon Together Control Human Coronavirus Infection, Propagation, and Neuropathology within the Central Nervous SystemAlain Le Coupanec, Marc Desforges, Benedikt Kaufer, Philippe Dubeau, Marceline Côté, Pierre J. Talbot
J Virol. 2021 May; 95(10): e00140-21. Prepublished online 2021 Feb 24. Published online 2021 Apr 26. doi: 10.1128/JVI.00140-21 PMCID: PMC8139659
Dynamic sumoylation of promoter-bound general transcription factors facilitates transcription by RNA polymerase IIMohammad S. Baig, Yimo Dou, Benjamin G. Bergey, Russell Bahar, Justin M. Burgener, Marjan Moallem, James B. McNeil, Akhi Akhter, Giovanni L. Burke, Veroni S. Sri Theivakadadcham, Patricia Richard, Damien D’Amours, Emanuel Rosonina
PLoS Genet. 2021 Sep; 17(9): e1009828. Published online 2021 Sep 29. doi: 10.1371/journal.pgen.1009828 PMCID: PMC8505008
The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation
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Nucleic Acids Res. 2021 Aug 20; 49(14): 8060–8077. Published online 2021 Jul 21. doi: 10.1093/nar/gkab617 PMCID: PMC8373147
HIRA stabilizes skeletal muscle lineage identity
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Nat Commun. 2021; 12: 3450. Published online 2021 Jun 8. doi: 10.1038/s41467-021-23775-9 PMCID: PMC8187366
Targeting Polyphosphate Kinases in the Fight against Pseudomonas aeruginosa
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mBio. 2021 Jul-Aug; 12(4): e01477-21. Published online 2021 Aug 3. doi: 10.1128/mBio.01477-21 PMCID: PMC8406150
Erratum for Bentley-DeSousa and Downey, “Vtc5 Is Localized to the Vacuole Membrane by the Conserved AP-3 Complex To Regulate Polyphosphate Synthesis in Budding Yeast”Amanda Bentley-DeSousa, Michael Downey
mBio. 2021 Nov-Dec; 12(6): e02997-21. Published online 2021 Nov 2. doi: 10.1128/mBio.02997-21
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Examining the Effects of an Anti-Salmonella Bacteriophage Preparation, BAFASAL®, on Ex-Vivo Human Gut Microbiome Composition and Function Using a Multi-Omics ApproachJanice Mayne, Xu Zhang, James Butcher, Krystal Walker, Zhibin Ning, Ewelina Wójcik, Jarosław Dastych, Alain Stintzi, Daniel Figeys
Viruses. 2021 Sep; 13(9): 1734. Published online 2021 Aug 31. doi: 10.3390/v13091734 PMCID: PMC8473076
Propionic acid disrupts endocytosis, cell cycle, and cellular respiration in yeast
Emma W. Micalizzi, Ashkan Golshani, Myron L. Smith
BMC Res Notes. 2021; 14: 335. Published online 2021 Aug 28. doi: 10.1186/s13104-021-05752-z PMCID: PMC8403364
The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLFMatthew Jessulat, Shahreen Amin, Mohsen Hooshyar, Ramy Malty, Mohamed Taha Moutaoufik, Mara Zilocchi, Zoe Istace, Sadhna Phanse, Hiroyuki Aoki, Katayoun Omidi, Daniel Burnside, Bahram Samanfar, Khaled A Aly, Ashkan Golshani, Mohan Babu
Nucleic Acids Res. 2021 Aug 20; 49(14): 8145–8160. Published online 2021 Jul 9. doi: 10.1093/nar/gkab585 PMCID: PMC8373142
Manganese-Induced Neurotoxicity through Impairment of Cross-Talk Pathways in Human Neuroblastoma Cell Line SH-SY5Y Differentiated with Retinoic AcidRaúl Bonne Hernández, Nadja C. de Souza-Pinto, Jos Kleinjans, Marcel van Herwijnen, Jolanda Piepers, Houman Moteshareie, Daniel Burnside, Ashkan Golshani
Toxics. 2021 Dec; 9(12): 348. Published online 2021 Dec 9. doi: 10.3390/toxics9120348 PMCID: PMC8704659
Dietary Cocoa Flavanols Enhance Mitochondrial Function in Skeletal Muscle and Modify Whole-Body Metabolism in Healthy MiceFrédéric Nicolas Daussin, Alexane Cuillerier, Julianne Touron, Samir Bensaid, Bruno Melo, Ali Al Rewashdy, Goutham Vasam, Keir J. Menzies, Mary-Ellen Harper, Elsa Heyman, Yan Burelle
Nutrients. 2021 Oct; 13(10): 3466. Published online 2021 Sep 29. doi: 10.3390/nu13103466 PMCID: PMC8538722
SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease
Marc-Olivier Deguise, Chantal Pileggi, Yves De Repentigny, Ariane Beauvais, Alexandra Tierney, Lucia Chehade, Jean Michaud, Maica Llavero-Hurtado, Douglas Lamont, Abdelmadjid Atrih, Thomas M. Wishart, Thomas H. Gillingwater, Bernard L. Schneider, Mary-Ellen Harper, Simon H. Parson, Rashmi Kothary
Cell Mol Gastroenterol Hepatol. 2021; 12(1): 354–377.e3. Published online 2021 Feb 2. doi: 10.1016/j.jcmgh.2021.01.019 PMCID: PMC8257458
Nuclear HKII-P-p53 (Ser15) Interaction is a Prognostic Biomarker for Chemoresponsiveness and Glycolytic Regulation in Epithelial Ovarian CancerChae Young Han, David A. Patten, Se Ik Kim, Jung Jin Lim, David W. Chan, Michelle K. Y. Siu, Youngjin Han, Euridice Carmona, Robin J. Parks, Cheol Lee, Li-Jun Di, Zhen Lu, Karen K. L. Chan, Ja-Lok Ku, Elizabeth A. Macdonald, Barbara C. Vanderhyden, Anne-Marie Mes-Masson, Hextan Y. S. Ngan, Annie N. Y. Cheung, Yong Sang Song, Robert C. Bast, Jr., Mary-Ellen Harper, Benjamin K. Tsang
Cancers (Basel) 2021 Jul; 13(14): 3399. Published online 2021 Jul 7. doi: 10.3390/cancers13143399 PMCID: PMC8306240
Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese womenKelly E. Mercer, Adrianna Maurer, Lindsay M. Pack, Kikumi Ono-Moore, Beverly J. Spray, Caitlin Campbell, Carol J. Chandler, Dustin Burnett, Elaine Souza, Gretchen Casazza, Nancy Keim, John Newman, Gary Hunter, Jose Fernadez, W. Timothy Garvey, Mary-Ellen Harper, Charles Hoppel, Sean H. Adams, John Thyfault
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PIGNON: a protein–protein interaction-guided functional enrichment analysis for quantitative proteomicsRachel Nadeau, Anastasiia Byvsheva, Mathieu Lavallée-Adam
BMC Bioinformatics. 2021; 22: 302. Published online 2021 Jun 4. doi: 10.1186/s12859-021-04042-6 PMCID: PMC8178832
PharmacoDB 2.0: improving scalability and transparency of in vitro pharmacogenomics analysis
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Orchestrating and sharing large multimodal data for transparent and reproducible research
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Nat Commun. 2021; 12: 5797. Published online 2021 Oct 4. doi: 10.1038/s41467-021-25974-w PMCID: PMC8490371
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
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Proteogenomic Characterization of Pancreatic Ductal Adenocarcinoma
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Highlights from the 16th International Society for Computational Biology Student Council Symposium 2020
Wim L. Cuypers, Handan Melike Dönertaş, Jasleen K. Grewal, Nazeefa Fatima, Chase Donnelly, Arvind Singh Mer, Spencer Krieger, Bart Cuypers, Farzana Rahman
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Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp InhibitorsAmarender Manchoju, Renaud Zelli, Gang Wang, Carla Eymard, Adrian Oo, Mona Nemer, Michel Prévost, Baek Kim, Yvan Guindon
Molecules. 2022 Jan; 27(2): 564. Published online 2022 Jan 17. doi: 10.3390/molecules27020564 PMCID: PMC8781509
WACS: improving ChIP-seq peak calling by optimally weighting controls
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BMC Bioinformatics. 2021; 22: 69. Published online 2021 Feb 15. doi: 10.1186/s12859-020-03927-2 PMCID: PMC7885521
FHR-5 Serum Levels and CFHR5 Genetic Variations in Patients With Immune Complex-Mediated Membranoproliferative Glomerulonephritis and C3-Glomerulopathy
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Antibody Response to mRNA Vaccines against SARS-CoV-2 with Chronic Kidney Disease, Hemodialysis, and after Kidney TransplantationLukas Buchwinkler, Claire Anne Solagna, Janosch Messner, Markus Pirklbauer, Michael Rudnicki, Gert Mayer, Julia Kerschbaum
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Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases
Danlei Zhou, Michael Rudnicki, Gilbert T. Chua, Simon K. Lawrance, Bi Zhou, Joanne L. Drew, Fatima Barbar-Smiley, Taylor K. Armstrong, Miranda E. Hilt, Daniel J. Birmingham, Werner Passler, Jeffrey J. Auletta, Sasigarn A. Bowden, Robert P. Hoffman, Yee Ling Wu, Wael N. Jarjour, Chi Chiu Mok, Stacy P. Ardoin, Yu Lung Lau, Chack Yung Yu
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Coregulation Analysis of Mechanistic Biomarkers in Autosomal Dominant Polycystic Kidney Disease
Johannes Leierer, Paul Perco, Benedikt Hofer, Susanne Eder, Alexander Dzien, Julia Kerschbaum, Michael Rudnicki, Gert Mayer
Int J Mol Sci. 2021 Jul; 22(13): 6885. Published online 2021 Jun 26. doi: 10.3390/ijms22136885 PMCID: PMC8269435
Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice
Marie-Claude Sincennes, Caroline E. Brun, Alexander Y. T. Lin, Tabitha Rosembert, David Datzkiw, John Saber, Hong Ming, Yoh-ichi Kawabe, Michael A. Rudnicki
Nat Commun. 2021; 12: 3253. Published online 2021 May 31. doi: 10.1038/s41467-021-23577-z PMCID: PMC8167170
STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancerStephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel
Nat Commun. 2021; 12: 3299. Published online 2021 Jun 3. doi: 10.1038/s41467-021-23396-2 PMCID: PMC8175605
Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancerShawn McGuirk, Yannick Audet-Delage, Matthew G Annis, Yibo Xue, Mathieu Vernier, Kaiqiong Zhao, Catherine St-Louis, Lucía Minarrieta, David A Patten, Geneviève Morin, Celia MT Greenwood, Vincent Giguère, Sidong Huang, Peter M Siegel, Julie St-Pierre
eLife. 2021; 10: e65150. Published online 2021 Jun 28. doi: 10.7554/eLife.65150 PMCID: PMC8238502
Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin
David Papadopoli, Oro Uchenunu, Ranveer Palia, Nabila Chekkal, Laura Hulea, Ivan Topisirovic, Michael Pollak, Julie St-Pierre
Neoplasia. 2021 Apr; 23(4): 391–399. Published online 2021 Mar 27. doi: 10.1016/j.neo.2021.02.003 PMCID: PMC8027095
Glycomacropeptide for Management of Insulin Resistance and Liver Metabolic Perturbations
Mathilde Foisy Sauvé, Francis Feldman, Mireille Koudoufio, Nour-El-Houda Ould-Chikh, Lena Ahmarani, Alain Sane, Thierry N’Timbane, Ramy El-Jalbout, Nathalie Patey, Schohraya Spahis, Alain Stintzi, Edgard Delvin, Emile Levy
Biomedicines. 2021 Sep; 9(9): 1140. Published online 2021 Sep 2. doi: 10.3390/biomedicines9091140 PMCID: PMC8469639
Factors contributing to fidelity in a pilot trial of individualized resistant starches for pediatric inflammatory bowel disease: a fidelity study protocolGisell Castillo, David R. Mack, Manoj M. Lalu, Ruth Singleton, Dean A. Fergusson, Alain Stintzi, Megan Harrison, Justin Presseau Pilot Feasibility Stud. 2021; 7: 75. Published online 2021 Mar 19. doi: 10.1186/s40814-021-00815-1 PMCID: PMC7976693
Oligosaccharides and Microbiota in Human Milk Are Interrelated at 3 Months Postpartum in a Cohort of Women with a High Prevalence of Gestational Impaired Glucose ToleranceLauren LeMay-Nedjelski, Chloe Yonemitsu, Michelle R Asbury, James Butcher, Sylvia H Ley, Anthony J Hanley, Alex Kiss, Sharon Unger, Julia K Copeland, Pauline W Wang, Alain Stintzi, Lars Bode, Deborah L O'Connor
J Nutr. 2021 Nov; 151(11): 3431–3441. Published online 2021 Sep 11. doi: 10.1093/jn/nxab270 PMCID: PMC8562078
Reduced Infection Efficiency of Phage NCTC 12673 on Non-Motile Campylobacter jejuni Strains Is Related to Oxidative StressJessica C. Sacher, Muhammad Afzal Javed, Clay S. Crippen, James Butcher, Annika Flint, Alain Stintzi, Christine M. Szymanski
Viruses. 2021 Oct; 13(10): 1955. Published online 2021 Sep 29. doi: 10.3390/v13101955 PMCID: PMC8540345
Critical appraisal of the mechanisms of gastrointestinal and hepatobiliary infection by COVID-19
Emile Levy, Alain Stintzi, Albert Cohen, Yves Desjardins, André Marette, Schohraya Spahis
Am J Physiol Gastrointest Liver Physiol. 2021 Aug 1; 321(2): G99–G112. Published online 2021 May 19. doi: 10.1152/ajpgi.00106.2021 PMCID: PMC8289353
Resistant starch, microbiome, and precision modulation
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Gut Microbes. 2021; 13(1): 1926842. Published online 2021 Jul 18. doi: 10.1080/19490976.2021.1926842 PMCID: PMC8288039
Expansion microscopy-based imaging of nuclear structures in cultured cells
Antoine Gaudreau-Lapierre, Kirk Mulatz, Jean-Claude Béïque, Laura Trinkle-Mulcahy
STAR Protoc. 2021 Sep 17; 2(3): 100630. Published online 2021 Jun 26. doi: 10.1016/j.xpro.2021.100630 PMCID: PMC8243706
DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster ModelLevi A. Tamming, Diana Duque, Anh Tran, Wanyue Zhang, Annabelle Pfeifle, Emmanuel Laryea, Jianguo Wu, Sathya N. Thulasi Raman, Caroline Gravel, Marsha S. Russell, Anwar M. Hashem, Reem M. Alsulaiman, Rowa Y. Alhabbab, Jun Gao, David Safronetz, Jingxin Cao, Lisheng Wang, Wangxue Chen, Michael J. W. Johnston, Simon Sauve, Michael Rosu-Myles, Xuguang Li
Front Immunol. 2021; 12: 785349. Published online 2022 Jan 12. doi: 10.3389/fimmu.2021.785349 PMCID: PMC8789660
Serum Untargeted UHPLC-HRMS-Based Lipidomics to Discover the Potential Biomarker of Colorectal Advanced AdenomaYifan Zhu, Lisheng Wang, Yanying Nong, Yunxiao Liang, Zongsheng Huang, Pingchuan Zhu, Qisong Zhang
Cancer Manag Res. 2021; 13: 8865–8878. Published online 2021 Nov 26. doi: 10.2147/CMAR.S336322 PMCID: PMC8632617
Single Immunization of a Vaccine Vectored by a Novel Recombinant Vaccinia Virus Affords Effective Protection Against Respiratory Syncytial Virus Infection in Cotton RatsMarsha S. Russell, Sathya N. Thulasi Raman, Caroline Gravel, Wanyue Zhang, Annabelle Pfeifle, Wangxue Chen, Gary Van Domselaar, David Safronetz, Michael Johnston, Simon Sauve, Lisheng Wang, Michael Rosu-Myles, Jingxin Cao, Xuguang Li
Front Immunol. 2021; 12: 747866. Published online 2021 Sep 17. doi: 10.3389/fimmu.2021.747866 PMCID: PMC8484905
Carbon Material Based Electrochemical Immunosensor for Gastric Cancer Markers Detection
Zhuliang Zhang, Minsi Peng, Defeng Li, Jun Yao, Yingxue Li, Benhua Wu, Lisheng Wang, Zhenglei Xu
Front Chem. 2021; 9: 736271. Published online 2021 Aug 31. doi: 10.3389/fchem.2021.736271 PMCID: PMC8438142
Graphene-Assisted Electrochemical Sensor for Detection of Pancreatic Cancer Markers
Zhenglei Xu, Minsi Peng, Zhuliang Zhang, Haotian Zeng, Ruiyue Shi, Xiaoxin Ma, Lisheng Wang, Bihong Liao
Front Chem. 2021; 9: 733371. Published online 2021 Aug 19. doi: 10.3389/fchem.2021.733371 PMCID: PMC8416602
Hollow-fiber bioreactor production of extracellular vesicles from human bone marrow mesenchymal stromal cells yields nanovesicles that mirrors the immuno-modulatory antigenic signature of the producer cellJonathan Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Lauren Couvrette, Andrew Stalker, Stewart Bigelow, Christian C. Luebbert, Frédéric St-Denis Bissonnette, Michael J. W. Johnston, Simon Sauvé, Roger Y. Tam, Lisheng Wang, Michael Rosu-Myles, Jessie R. Lavoie
Stem Cell Res Ther. 2021; 12: 127. Published online 2021 Feb 12. doi: 10.1186/s13287-021-02190-3 PMCID: PMC7880218
Long noncoding RNA KIF9-AS1 promotes cell apoptosis by targeting the microRNA-148a-3p/suppressor of cytokine signaling axis in inflammatory bowel diseaseJun Yao, Ruoyu Gao, Minghan Luo, Defeng Li, Liliangzi Guo, Zichao Yu, Feng Xiong, Cheng Wei, Benhua Wu, Zhenglei Xu, Dingguo Zhang, Jianyao Wang, Lisheng Wang
Eur J Gastroenterol Hepatol. 2021 Dec; 33(Suppl 1): e922–e932. Published online 2021 Nov 8. doi: 10.1097/MEG.0000000000002309 PMCID: PMC8734634
Identification of Active Ingredients of Huangqi Guizhi Wuwu Decoction for Promoting Nerve Function Recovery After Ischemic Stroke Using HT22 Live-Cell-Based Affinity Chromatography Combined with HPLC-MS/MSYingying He, Haozhen Zheng, Lanying Zhong, Nijun Zhong, Guiqing Wen, Lisheng Wang, Ying Zhang
Drug Des Devel Ther. 2021; 15: 5165–5178. Published online 2021 Dec 30. doi: 10.2147/DDDT.S333418 PMCID: PMC8722572
COVID-MTL: Multitask learning with Shift3D and random-weighted loss for COVID-19 diagnosis and severity assessmentGuoqing Bao, Huai Chen, Tongliang Liu, Guanzhong Gong, Yong Yin, Lisheng Wang, Xiuying Wang
Pattern Recognit. 2022 Apr; 124: 108499. Published online 2021 Dec 12. doi: 10.1016/j.patcog.2021.108499 PMCID: PMC8666107
Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineagesCaroline Gravel, Abenaya Muralidharan, Amparo Duran, Adrian Zetner, Annabelle Pfeifle, Wanyue Zhang, Anwar Hashem, Levi Tamming, Aaron Farnsworth, Hugues Loemba, Wangxue Chen, Florian Krammer, David Safronetz, Jingxin Cao, Lisheng Wang, Simon Sauve, Michael Rosu-Myles, Gary Van Domselaar, Xuguang Li
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Quantitative Prediction of Microsatellite Instability in Colorectal Cancer With Preoperative PET/CT-Based RadiomicsJiaru Li, Ziyi Yang, Bowen Xin, Yichao Hao, Lisheng Wang, Shaoli Song, Junyan Xu, Xiuying Wang
Front Oncol. 2021; 11: 702055. Published online 2021 Jul 22. doi: 10.3389/fonc.2021.702055 PMCID: PMC8339969
Correction to: Automatic identification of myopic maculopathy related imaging features in optic disc region via machine learning methodsYuchen Du, Qiuying Chen, Ying Fan, Jianfeng Zhu, Jiangnan He, Haidong Zou, Dazhen Sun, Bowen Xin, David Feng, Michael Fulham, Xiuying Wang, Lisheng Wang, Xun Xu
J Transl Med. 2021; 19: 203. Published online 2021 May 11. doi: 10.1186/s12967-021-02874-7 Corrects: J Transl Med. 2021; 19: 167. PMCID: PMC8114694
Expression of Nutrient Transporters on NK Cells During Murine Cytomegalovirus Infection Is MyD88-DependentAbrar Ul Haq Khan, Saeedah Musaed Almutairi, Alaa Kassim Ali, Rosalba Salcedo, C. Andrew Stewart, Lisheng Wang, Seung-Hwan Lee Front Immunol. 2021; 12: 654225. Published online 2021 May 3. doi: 10.3389/fimmu.2021.654225 PMCID: PMC8177011
Imaging Features by Machine Learning for Quantification of Optic Disc Changes and Impact on Choroidal Thickness in Young Myopic PatientsDandan Sun, Yuchen Du, Qiuying Chen, Luyao Ye, Huai Chen, Menghan Li, Jiangnan He, Jianfeng Zhu, Lisheng Wang, Ying Fan, Xun Xu
Front Med (Lausanne) 2021; 8: 657566. Published online 2021 Apr 29. doi: 10.3389/fmed.2021.657566 PMCID: PMC8116583
Post-Alignment Adjustment and Its Automation
Xuhua Xia
Genes (Basel) 2021 Nov; 12(11): 1809. Published online 2021 Nov 18. doi: 10.3390/genes12111809 PMCID: PMC8623120
Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines
Xuhua Xia
Vaccines (Basel) 2021 Jul; 9(7): 734. Published online 2021 Jul 3. doi: 10.3390/vaccines9070734 PMCID: PMC8310186
Applications of Protein Secondary Structure Algorithms in SARS-CoV-2 Research
Alibek Kruglikov, Mohan Rakesh, Yulong Wei, Xuhua Xia
J Proteome Res. 2021 Mar 5; 20(3): 1457–1463. Published online 2021 Feb 22. doi: 10.1021/acs.jproteome.0c00734 PMCID: PMC7927282
Author Correction: Predicting mammalian species at risk of being infected by SARS-CoV-2 from an ACE2 perspectiveYulong Wei, Parisa Aris, Heba Farookhi, Xuhua Xia
Sci Rep. 2021; 11: 22016. Published online 2021 Nov 4. doi: 10.1038/s41598-021-01576-w
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Dating the Common Ancestor from an NCBI Tree of 83688 High-Quality and Full-Length SARS-CoV-2 GenomesXuhua Xia
Viruses. 2021 Sep; 13(9): 1790. Published online 2021 Sep 8. doi: 10.3390/v13091790 PMCID: PMC8472983
Does Saccharomyces cerevisiae Require Specific Post-Translational Silencing against Leaky Translation of Hac1up?
Ali Tehfe, Talia Roseshter, Yulong Wei, Xuhua Xia
Microorganisms. 2021 Mar; 9(3): 620. Published online 2021 Mar 17. doi: 10.3390/microorganisms9030620 PMCID: PMC8002603