G protein-coupled receptors (GPCRs) represent the most diverse class of human receptor having key roles in an incredible array of functions in human body as well as many pathophysiological conditions. The discovery of modulators of these receptors and our increase understanding has greatly affected modern medicine. In fact, we estimate that between one-third to one-half of currently marketed drugs act through GPCRs making them the most common and extensive validated class of therapeutic targets.
The overall goal of our research is to enhance, improve, accelerate and facilitate the discovery or the development of new GPCRs modulators. Our lab employs pharmacological, biochemical and structural approaches to develop a new level of understanding of GPCR ligand molecular recognition, pharmacology and functional selectivity as well as through the creation of innovative drugs discovery platforms and tools. To achieve our research goals, we uses various state-of-the-art high-throughput cellular screening system and assays. Some of the active targets in the lab include the opioid receptor system and amine GPCRs. We believe that the development of functionally selective allosteric modulators will allow the development of drugs which can remotely control these receptors with reduce side effects and problems associated with tolerance, dependence or overdose, and would overcome the caveats of orthosteric-targeting drugs.
The Giguère lab supervises students from the graduate program in Biochemistry but welcome further supervisions in other programs as co-supervisor.
Lab website: https://med.uottawa.ca/bmi/people/giguere-patrick