Not all of the listed courses are given each year. The course is offered in the language in which it is described.
BCH5101 ANALYSIS OF –OMICS DATA (3 units)
Theoretical and practical aspects of various methods currently used to analyze the plethora mountain of –omics data. Methods: sequence alignment and database searches; sequence analysis and bioinformatics of gene regulation; DNA microarray and sequencing technologies to identify transcription factor binding sites; analysis of proteomics data; statistical analysis of preprocessed gene expression and protein/metabolite abundance data; epidemiology applications. Critical reading of the literature and strategies for making informed choices of methods for the analysis of students’ own data. Prerequisites: BCH2333, BCH3170.
BCH5366 MSc SEMINAR (3 units)
Attendance and participation in the annual BMI Student Symposium and BMI Poster Day, attendance at BMI seminars relevant to Biochemistry. Students must present at least one poster and one oral presentation during the course of their program. Graded S/NS
BCH7999 RECHERCHE POUR LA THÈSE DE MAÎTRISE / MSC THESIS RESEARCH
À l'intention des étudiants faisant de la recherche en vue de l'obtention de la maîtrise. Les étudiants doivent soumettre au Département un plan détaillé de la recherche qu'ils se proposent de faire. Ils doivent rencontrer leur comité consultatif de thèse au moins une fois par année et soumettre un rapport de progrès au Département. / For students doing research leading to the master’s degree. Students must ensure that a detailed outline of their proposed research is on file with the Department. They must meet at least once per year with their thesis advisory committee and submit a progress report to the Department.
BCH8101 PHYSICAL AND CHEMICAL METHODS IN BIOCHEMISTRY (3 units)
Current applications of physical and chemical methods to the study of macromolecule structure-function relationships.
BCH8102 SELECTED TOPICS IN PROTEIN STRUCTURE AND FUNCTION (3 units)
An advanced study of recent literature dealing with structure-function relationships in selected proteins.
BCH8103 ADVANCED TOPICS IN GENE EXPRESSION AND PROTEIN SYNTHESIS (3 units)
An advanced study of the recent literature dealing with the chemistry, metabolism and function of nucleic acids, the biosynthesis of proteins, biochemical and genetic control mechanisms, genetic engineering and the control of gene expression. Offered every second year in alternation with BCH8105. Prerequisite: BPS 4101 or equivalent with the permission of the instructor.
BCH8104 ADVANCED TOPICS IN CELL REGULATION (3 units)
An advanced study of recent literature dealing with signal transduction processes and the regulation of metabolism, cell proliferation and differentiation. Prerequisites: Offered in alternate years.
BCH8105 ADVANCED TOPICS IN MOLECULAR BIOLOGY OF HUMAN DISEASES (3 units)
Topics will be selected and representative of current developments in the field. The course consists of a repeated series of a 3 hour lecture by an expert in the field one week, followed by student presentations, discussions and critique of assigned papers on that topic the following week. Topics on selected diseases will focus on various aspects of cancer, apoptosis, disease gene identification and gene therapy. In the past these topics have included the molecular aspects of various cancers, spinal muscular atrophy, tissue regeneration, the discovery of disease genes, infectious disease (HIV) and gene therapy. Students will write a grant proposal and participate in mock grant review panels. Depending on enrolment, the course may be limited to HMG students only. Prerequisite: Permission of the HMG program director.
BCH8106 ADVANCED TOPICS IN NUTRITION AND REGULATION OF METABOLISM (3 units)
An advanced study of the recent literature dealing with metabolism, nutrition and metabolic control theory, with emphasis on both whole body and cell metabolism in metabolic and nutritional disorders such as obesity and non-insulin-dependent diabetes mellitus (NIDDM).
BCH8107 ADVANCED TOPICS IN STRUCTURE AND FUNCTION OF PLASMA LIPOPROTEINS (3 units)
Recent advances in our knowledge of the plasma lipoproteins with a special emphasis on their role in the etiology of atherosclerosis. The subject will be introduced by an overview of the general structural properties of lipoproteins which will be followed by detailed discussion of the structure, metabolism and genetics of the apolipoproteins, the proteins and enzymes that modify lipoproteins and cell surface lipoprotein receptors. Other topics will include cholesterol homeostasis, plasma cholesterol transport and disorders of lipoprotein metabolism.
BCH8108 ADVANCED METHODS OF MACROMOLECULAR STRUCTURE DETERMINATION (3 units)
A detailed examination of modern methods used to determine the structures of proteins, nucleic acids, and carbohydrates. May include X-ray crystallography, electron diffraction, nuclear magnetic resonance, and other spectroscopic methods.
BCH8109 ADVANCED TOPICS IN CELL DEATH (3 units)
Molecular mechanisms of cell death. Particular attention to be paid to role of aberrant cell death in human disease. Offered in the Fall of odd numbered years.
BCH8110 ADVANCED TOPICS IN SYSTEMS BIOLOGY (3 units)
Recent advances in genomics, proteomics, bioinformatics, and neuroinformatics including functional and chemical genomics, RNA analyses, microarrays, mass spectrometry, and neural imaging. Course requirements include student presentations and writing a mock research proposal based on Canadian Institutes of Health Research (CIHR) guidelines. Limited enrollment. Offered in alternate years with BCH 8101 Physical and Chemical Methods in Biochemistry. Prerequisite: Permission of the program director.
BCH8111 CHROMOSOME AND CHROMATIN BIOLOGY (3 units)
Higher order chromosome structure and chromatin remodeling and their impact on regulation of gene expression, DNA replication, repair and recombination, and chromosome segregation. Histone modifications and nucleosome positioning and their influence on higher order chromosome structure. Importance of chromosome and chromatin in the context of the cell cycle, development, and disease. Critical reading of the literature on chromosome and chromatin biology.
BCH8114 ADVANCED TOPICS IN THE CELL CYCLE (3 units)
Mechanisms of cell cycle regulation. Model systems critical to deciphering the cell cycle in eukaryotes: budding and fission yeast, Xenopus laevis egg extracts, Aspergillus nidulans, Drosophila melanogaster, sea urchin and mouse oocytes and cultured vertebrate cells. Overview of the prokaryotic cell cycle.
BCH8116 MODEL ORGANISMS AND SYSTEMS BIOLOGY (3 units)
Utilization of model organisms in the development and advancement of the systems biology field. Particular attention will be paid to the use of organisms such as Saccharomyces cerevisiae as a model platform for cell cycle progression/cancer. Other models may also be included. The basics of the technology will be discussed along with the application of technology to complex biological questions, in particular relating to the cell cycle. Course offered in alternate years.
BCH8117 ADVANCED TOPICS RELATING TO THE CELL CYTOSKELETON AND MEMBRANES (3 units)
Advanced study of recent literature dealing with the mammalian cellular cytoskeleton and membrane with an emphasis on the regulation of cell motility, adhesion and cell division.
BCH8134 STRUCTURE AND EXPRESSION OF EUKARYOTIC AND PROKARYOTIC GENOMES (3 units)
Sequencing of eukaryote and prokaryote genomes with emphasis on
recent technologies, sequence alignments and databases and assembly of genomes from massively parallel sequencing data. Focus on mapping studies, including linkage disequilibrium-based genome-wide association study (GWAS), to characterize functional variants associated with complex traits. Analysis and structure of microbial metagenomes from environmental and human habitats, including structure-function analysis of microbial communities, microbiota-human disease correlations, and molecular phylogeny. Genome expression, including measures of RNA transcripts and proteins and statistical analysis of data. Combination of various -omics data to understand gene-environment interactions.
BCH8165 SPECIAL TOPICS IN BIOCHEMISTRY I (3 units)
A survey of recent advances in selected areas of biochemistry.
BCH8166 Special Topics in Biochemistry II (3 units)
A survey of recent advances in selected areas of biochemistry.
BCH8310 CURRENT TOPICS IN RNA MOLECULAR BIOLOGY (3 units)
Properties, mechanisms associated with regulation and the functions of RNAs and Ribonucleoprotein (RNPs) as well as RNA organisms. Current knowledge on RNA expression (synthesis, processing, transport and localization), the structure-function relationship and molecular mechanisms associated with RNAs and RNA genomes, RNA in evolution and in the origin of life, and RNA as therapeutic agents. Prerequisites: BCH/BIO 3570-3170 or equivalent with the permission of the program director. Exclusion : CMM 8310.
BCH8366 PhD SEMINAR (3 units)
Attendance and participation in the annual BMI Student Symposium and BMI Poster Day, attendance at BMI seminars relevant to Biochemistry. Students will present a poster in their first and every alternate year, and an oral presentation the second and every alternate year until they have permission to write their thesis. Graded S/NS
BCH9998 EXAMEN DE SYNTHÈSE (DOCTORAT) / COMPREHENSIVE EXAMINATION (PhD)
À l'intention des étudiants inscrits au programme de Ph.D. L'inscription à ce cours est limitée à trois sessions consécutives. / For students enrolled in the doctoral program. Enrollement in this course is limited to three consecutive academic sessions.
BCH9999 RECHERCHE POUR LA THÈSE DE DOCTORAT / DOCTORAL THESIS RESEARCH
À l'intention des étudiants faisant de la recherche en vue de l'obtention du doctorat. Les étudiants doivent soumettre au Département un plan détaillé de la recherche qu'ils se proposent de faire. Ils doivent rencontrer leur comité consultatif de thèse au moins une fois par année et soumettre un rapport de progrès au Département. / For students doing research leading to the doctoral degree. Students must ensure that a detailed outline of their proposed research is on file with the Department. They must meet at least once per year with their thesis advisory committee and submit a progress report to the Department.
CMM5315 CELLULAR AND MOLECULAR BASIS OF CARDIOVASCULAR FUNCTION/DYSFUNCTION (3 units)
Mechanism of failing heart and cardiovascular system, its associated functions and associated conditions. Therapies for restoring function. Topics include: regulation of heart development, cell signaling, cellular and molecular mechanisms of atherosclerosis and heart disease, hormonal regulation, hypertension, bioenergetics, cardiovascular genomics and genetics, cell therapy, and regenerative medicine.
HMG8106 CLINICAL CYTOGENOMICS (3 units)
Comprehensive review of the basic principles and technologies in cytogenomics and their clinical application for diagnostic and prognostic purposes. Registrations may be limited depending on enrolment. Prerequisite: Permission of the course coordinator.
HMG8107 CLINICAL BIOCHEMICAL GENETICS (3 units)
Presentation of the biomechanical and molecular bases of inborn errors of metabolism. The course consists of a series of lectures followed by student discussion of a related paper assigned the previous week. Registrations may be limited depending on enrolment. Prerequisite: Permission of the course coordinator.
HMG8108 CLINICAL MOLECULAR GENETICS (3 units)
Comprehensive review of all aspects of clinical molecular genetics acquainting students with clinical applications of various molecular technologies. Registrations may be limited depending on enrolment. Prerequisite: Permission of the course coordinator.
MED8166 PROFESSIONALISM AND PROFESSIONAL SKILLS
Basic professional skills related to academic integrity, proper referencing techniques, avoidance of plagiarism, professional etiquette, public speaking, time and stress management, conflict management, teamwork, knowing when and how to access student support services. Compulsory for all students enrolled in master’s or doctoral programs at the Faculty of Medicine. Graded S/NS (Satisfactory/Not satisfactory).